Literature DB >> 1915563

Glucocorticoids suppress the production of interleukin 4 by human lymphocytes.

C Y Wu1, C Fargeas, T Nakajima, G Delespesse.   

Abstract

Given that glucocorticoids (GCS) were reported to increase the production of interleukin 4 (IL4) by mouse T cells and that GCS are widely used to treat allergic diseases it was important to examine the effect of these agents on IL4 production by human lymphocytes. We here demonstrate that the production of IL4 by human lymphocytes is markedly inhibited by small concentrations of hydrocortisone. The suppression is observed at the protein and at the mRNA levels and it is not secondary to the GCS-induced inhibition of IL2 production.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1915563     DOI： 10.1002/eji.1830211053

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  21 in total

1.  The role of endogenous steroid hormones in the generation of T helper 2-mediated autoimmunity in mercuric chloride-treated Brown-Norway rats.

Authors:  I A MacPhee; D R Turner; D B Oliveira
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

Review 2.  Asthma phenotypes: the evolution from clinical to molecular approaches.

Authors:  Sally E Wenzel
Journal:  Nat Med       Date:  2012-05-04       Impact factor: 53.440

3.  Glucocorticoids enhance concanavalin A-induced mitogenic response through the inhibition of nitric oxide production.

Authors:  F Ramírez; A Silva
Journal:  Immunology       Date:  1997-01       Impact factor: 7.397

Review 4.  A gradient of glucocorticoid sensitivity among helper T cell cytokines.

Authors:  Jesus Banuelos; Nicholas Z Lu
Journal:  Cytokine Growth Factor Rev       Date:  2016-05-13       Impact factor: 7.638

5.  Effects of systemic versus local administration of corticosteroids on mucosal tolerance.

Authors:  Jerome Kerzerho; Daniela Wunsch; Natacha Szely; Hellmuth-Alexander Meyer; Lisa Lurz; Lars Röse; Ulrich Wahn; Omid Akbari; Philippe Stock
Journal:  J Immunol       Date:  2011-11-21       Impact factor: 5.422

Review 6.  An overview of glucocorticoid anti-inflammatory actions.

Authors:  R P Schleimer
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

Review 7.  Regulation of IgE synthesis: from the membrane to the genes.

Authors:  D Vercelli; R S Geha
Journal:  Springer Semin Immunopathol       Date:  1993

8.  Induction of interleukin-4 and interleukin-5 expression in mast cells is inhibited by glucocorticoids.

Authors:  W A Sewell; L L Scurr; H Orphanides; S Kinder; R I Ludowyke
Journal:  Clin Diagn Lab Immunol       Date:  1998-01

9.  Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis.

Authors:  K Masuyama; M R Jacobson; S Rak; Q Meng; R M Sudderick; A B Kay; O Lowhagen; Q Hamid; S R Durham
Journal:  Immunology       Date:  1994-06       Impact factor: 7.397

10.  Inhibition of interleukin-5 gene expression by dexamethasone.

Authors:  F G Rolfe; J M Hughes; C L Armour; W A Sewell
Journal:  Immunology       Date:  1992-12       Impact factor: 7.397
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.