OBJECTIVE: To evaluate the effectiveness of a new off-pump mitral valve repair technology in restoring valve competency in a porcine model of acute mitral regurgitation. METHODS: Acute mitral regurgitation was induced in 6 anesthetized pigs by cutting anterior leaflet chordae. Artificial chordae were then transapically implanted on the prolapsing segment under epicardial echocardiographic guidance and secured outside the left ventricular apex. All intracardiac manipulations were performed off-pump, through a stab wound incision on the left ventricular apex. RESULTS: Cutting the anterior leaflet chordae caused an eccentric, posteriorly directed jet of mitral regurgitation that could be visualized by color Doppler sonography. Implantation of chordae through the left ventricular apex completely eliminated valve regurgitation in 4 animals and reduced regurgitation in 2. Intraoperative measurement of artificial chordal tensions gave similar values to those reported for native chordae. CONCLUSIONS: Off-pump, transapical implantation of artificial chordae between a prolapsing anterior mitral valve leaflet and the left ventricular apex was effective in reducing acutely induced mitral regurgitation. Long-term studies are planned to assess the stability in this animal model.
OBJECTIVE: To evaluate the effectiveness of a new off-pump mitral valve repair technology in restoring valve competency in a porcine model of acute mitral regurgitation. METHODS: Acute mitral regurgitation was induced in 6 anesthetized pigs by cutting anterior leaflet chordae. Artificial chordae were then transapically implanted on the prolapsing segment under epicardial echocardiographic guidance and secured outside the left ventricular apex. All intracardiac manipulations were performed off-pump, through a stab wound incision on the left ventricular apex. RESULTS: Cutting the anterior leaflet chordae caused an eccentric, posteriorly directed jet of mitral regurgitation that could be visualized by color Doppler sonography. Implantation of chordae through the left ventricular apex completely eliminated valve regurgitation in 4 animals and reduced regurgitation in 2. Intraoperative measurement of artificial chordal tensions gave similar values to those reported for native chordae. CONCLUSIONS: Off-pump, transapical implantation of artificial chordae between a prolapsing anterior mitral valve leaflet and the left ventricular apex was effective in reducing acutely induced mitral regurgitation. Long-term studies are planned to assess the stability in this animal model.
Authors: Joerg Seeburger; Hugo A Katus; Sven T Pleger; Ulrike Krumsdorf; Friedrich-Wilhelm Mohr; Raffi Bekeredjian Journal: Dtsch Arztebl Int Date: 2011-12-02 Impact factor: 5.594
Authors: Israel M Barbash; Christina E Saikus; Kanishka Ratnayaka; Anthony Z Faranesh; Ozgur Kocaturk; Vincent Wu; Jamie A Bell; William H Schenke; Venkatesh K Raman; Robert J Lederman Journal: Catheter Cardiovasc Interv Date: 2011-03-21 Impact factor: 2.692
Authors: Nikolay V Vasilyev; Mitsuhiro Kawata; Christopher M DiBiasio; Keith V Durand; Jonathan Hopkins; Zachary J Traina; Alexander H Slocum; Pedro J del Nido Journal: J Thorac Cardiovasc Surg Date: 2011-09-08 Impact factor: 5.209