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Literature DB >> 19154335

A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism?

Matteo Caleo¹, Flavia Antonucci, Laura Restani, Riccardo Mazzocchio.

Abstract

Botulinum neurotoxin A (BoNT/A) is a metalloprotease that enters peripheral motor nerve terminals and blocks the release of acetylcholine via the specific cleavage of the synaptosomal-associated protein of 25-kDa. Localized injections of BoNT/A are widely employed in clinical neurology to treat several human diseases characterized by muscle hyperactivity. It is generally assumed that the effects of BoNT/A remain localized to the injection site. However, several neurophysiological studies have provided evidence for central effects of BoNT/A, raising the issue of how these actions arise. Here we review these data and discuss the possibility that retrograde axonal transport of catalytically active BoNT/A may explain at least some of its effects at the level of central circuits.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Botulinum Toxins, Type A

Year: 2009 PMID： 19154335 DOI： 10.1111/j.1471-4159.2009.05887.x

Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372

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Cited

27 in total

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Journal: J Spinal Cord Med Date: 2019-04-18 Impact factor: 1.985

2. Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons.

Authors: Ewa Bomba-Warczak; Jason D Vevea; Joel M Brittain; Annette Figueroa-Bernier; William H Tepp; Eric A Johnson; Felix L Yeh; Edwin R Chapman
Journal: Cell Rep Date: 2016-08-04 Impact factor: 9.423

3. Multiple domains of tetanus toxin direct entry into primary neurons.

Authors: Faith C Blum; William H Tepp; Eric A Johnson; Joseph T Barbieri
Journal: Traffic Date: 2014-08-11 Impact factor: 6.215

Review 4. Botulinum toxin type A in motor nervous system: unexplained observations and new challenges.

Authors: I Matak; Z Lacković; M Relja
Journal: J Neural Transm (Vienna) Date: 2016-09-01 Impact factor: 3.575

5. Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.

Authors: Erkan Kiris; Jonathan E Nuss; James C Burnett; Krishna P Kota; Dawn C Koh; Laura M Wanner; Edna Torres-Melendez; Rick Gussio; Lino Tessarollo; Sina Bavari
Journal: Stem Cell Res Date: 2011-01-19 Impact factor: 2.020

10. Long-lasting attenuation of amygdala-kindled seizures after convection-enhanced delivery of botulinum neurotoxins a and B into the amygdala in rats.

Authors: Maciej Gasior; Rebecca Tang; Michael A Rogawski
Journal: J Pharmacol Exp Ther Date: 2013-06-14 Impact factor: 4.030

A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism?

1. Intravesical electromotive administration of botulinum toxin type A in improving the bladder and bowel functions: Evidence for novel mechanism of action.

2. Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons.

3. Multiple domains of tetanus toxin direct entry into primary neurons.

Review 4. Botulinum toxin type A in motor nervous system: unexplained observations and new challenges.

5. Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.

6. None detectable retrograde transport of Chinese botulinum toxin type A in mice by single intramuscular injection.

Review 7. An update on the neurologic applications of botulinum toxins.

8. Beyond muscular effects: depression of spinal recurrent inhibition after botulinum neurotoxin A.

9. Silencing synapses: a route to understanding synapse degeneration in chronic neurodegenerative disease.

10. Long-lasting attenuation of amygdala-kindled seizures after convection-enhanced delivery of botulinum neurotoxins a and B into the amygdala in rats.