INTRODUCTION: Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay. CLINICAL PRESENTATION: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs. SUMMARY: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.
INTRODUCTION:Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay. CLINICAL PRESENTATION: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs. SUMMARY: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.
Authors: C M Frattali; K Liow; G H Craig; L M Korenman; F Makhlouf; S Sato; L G Biesecker; W H Theodore Journal: Neurology Date: 2001-07-10 Impact factor: 9.910
Authors: Y Fujimoto; A Kato; Y Saitoh; H Ninomiya; K Imai; R I Sakakibara; M Maruno; H Kishima; K Yoshimura; H Hasegawa; T Yoshimine Journal: Acta Neurochir (Wien) Date: 2003-08 Impact factor: 2.216
Authors: Zdeněk Vojtěch; Hana Malíková; Martin Syrůček; Lenka Krámská; Jan Šroubek; Vilibald Vladyka; Roman Liščák Journal: Acta Neurochir (Wien) Date: 2015-08-16 Impact factor: 2.216