Erica A Eugster1. 1. Section of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind., USA. eeugster@iupui.edu
Abstract
BACKGROUND: Peripheral precocious puberty (PPP) results from sex steroid exposure by a process other than activation of the hypothalamic-pituitary-gonadal axis. It is much less common than central precocious puberty and may be congenital or acquired. Causes of PPP range from well-characterized genetic mutations to those conditions without a known etiology (idiopathic). Medical evaluation and treatment of affected children is guided by the presenting features and ultimate diagnosis. CONCLUSIONS: Carefully executed and collaborative multicenter investigations are essential to expand our knowledge of the underlying pathophysiology, optimal therapy and ultimate outcomes in children with PPP. Copyright 2009 S. Karger AG, Basel.
BACKGROUND: Peripheral precocious puberty (PPP) results from sex steroid exposure by a process other than activation of the hypothalamic-pituitary-gonadal axis. It is much less common than central precocious puberty and may be congenital or acquired. Causes of PPP range from well-characterized genetic mutations to those conditions without a known etiology (idiopathic). Medical evaluation and treatment of affected children is guided by the presenting features and ultimate diagnosis. CONCLUSIONS: Carefully executed and collaborative multicenter investigations are essential to expand our knowledge of the underlying pathophysiology, optimal therapy and ultimate outcomes in children with PPP. Copyright 2009 S. Karger AG, Basel.
Authors: Huda A Osman; Nasir A M Al-Jurayyan; Amir M I Babiker; Hessah M N Al-Otaibi; Reem D H AlKhalifah; Sharifah D A Al Issa; Sarar Mohamed Journal: Sudan J Paediatr Date: 2017