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Literature DB >> 19152862

Fluorescent pteridine probes for nucleic acid analysis.

Abstract

This chapter is focused on the fluorescent pteridine guanine analogs, 3MI and 6MI and on the pteridine adenine analog, 6MAP. A brief overview of commonly used methods to fluorescently label oligonucleotides reveals the role the pteridines play in the extensive variety of available probes. We describe the fluorescence characteristics of the pteridine probes as monomers and incorporated into DNA and review a variety of applications including changes in fluorescence intensity, anisotropies, time resolved studies, two photon excitation and single molecule detection.

Entities: Chemical

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Year: 2008 PMID： 19152862 DOI： 10.1016/S0076-6879(08)03410-1

Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600

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Cited

15 in total

1. DNA conformational changes at the primer-template junction regulate the fidelity of replication by DNA polymerase.

Authors: Kausiki Datta; Neil P Johnson; Peter H von Hippel
Journal: Proc Natl Acad Sci U S A Date: 2010-10-04 Impact factor: 11.205

2. Modified 6-aza uridines: highly emissive pH-sensitive fluorescent nucleosides.

Authors: Renatus W Sinkeldam; Patrycja A Hopkins; Yitzhak Tor
Journal: Chemphyschem Date: 2012-07-06 Impact factor: 3.102

Review 3. Fluorescent analogs of biomolecular building blocks: design, properties, and applications.

Authors: Renatus W Sinkeldam; Nicholas J Greco; Yitzhak Tor
Journal: Chem Rev Date: 2010-05-12 Impact factor: 60.622

4. Closed for business: exit-channel coupling to active site conformation in bacterial RNA polymerase.

Authors: Craig T Martin; Karsten Theis
Journal: Nat Struct Mol Biol Date: 2014-09 Impact factor: 15.369

5. Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels.

Authors: Marianna Sholokh; Roberto Improta; Mattia Mori; Rajhans Sharma; Cyril Kenfack; Dongwon Shin; Karine Voltz; Roland H Stote; Olga A Zaporozhets; Maurizio Botta; Yitzhak Tor; Yves Mély
Journal: Angew Chem Int Ed Engl Date: 2016-06-08 Impact factor: 15.336

6. Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue.

Authors: Renatus W Sinkeldam; Lisa S McCoy; Dongwon Shin; Yitzhak Tor
Journal: Angew Chem Int Ed Engl Date: 2013-11-29 Impact factor: 15.336

Fluorescent pteridine probes for nucleic acid analysis.

1. DNA conformational changes at the primer-template junction regulate the fidelity of replication by DNA polymerase.

2. Modified 6-aza uridines: highly emissive pH-sensitive fluorescent nucleosides.

Review 3. Fluorescent analogs of biomolecular building blocks: design, properties, and applications.

4. Closed for business: exit-channel coupling to active site conformation in bacterial RNA polymerase.

5. Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels.

6. Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue.

7. Applying 6-methylisoxanthopterin-enhanced fluorescence to examine protein-DNA interactions in the picomolar range.

8. Use of a Pteridine Moiety to Track DNA Uptake in Cells.

9. Quadruplex formation as a molecular switch to turn on intrinsically fluorescent nucleotide analogs.

10. Electronic transition moments of 6-methyl isoxanthopterin--a fluorescent analogue of the nucleic acid base guanine.