Literature DB >> 19152630

The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential.

Olayiwola A Adekoya1, Ingebrigt Sylte.   

Abstract

Zinc containing peptidases are widely distributed in nature and have important roles in many physiological processes. M4 family comprises numerous zinc-dependent metallopeptidases that hydrolyze peptide bonds. A large number of these enzymes are implicated as virulence factors of the microorganisms that produce them and are therefore potential drug targets. Some enzymes of the family are able to function at the extremes of temperatures, and some function in organic solvents. Thereby enzymes of the thermolysin family have an innovative potential for biotechnological applications.

Mesh:

Substances:

Year:  2009        PMID: 19152630     DOI: 10.1111/j.1747-0285.2008.00757.x

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN: 1747-0277            Impact factor:   2.817


  27 in total

1.  Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family.

Authors:  Xiang Gao; Jue Wang; Da-Qi Yu; Fei Bian; Bin-Bin Xie; Xiu-Lan Chen; Bai-Cheng Zhou; Lu-Hua Lai; Zhi-Xin Wang; Jia-Wei Wu; Yu-Zhong Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-27       Impact factor: 11.205

Review 2.  Architecture and function of metallopeptidase catalytic domains.

Authors:  Núria Cerdà-Costa; Francesc Xavier Gomis-Rüth
Journal:  Protein Sci       Date:  2014-02       Impact factor: 6.725

3.  Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa.

Authors:  Li Ma; Lizhen Zhou; Jinshui Lin; Jiuyuan Ji; Yang Wang; Haobo Jiang; Xihui Shen; Zhiqiang Lu
Journal:  Dev Comp Immunol       Date:  2018-09-24       Impact factor: 3.636

4.  What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira.

Authors:  Derrick E Fouts; Michael A Matthias; Haritha Adhikarla; Ben Adler; Luciane Amorim-Santos; Douglas E Berg; Dieter Bulach; Alejandro Buschiazzo; Yung-Fu Chang; Renee L Galloway; David A Haake; Daniel H Haft; Rudy Hartskeerl; Albert I Ko; Paul N Levett; James Matsunaga; Ariel E Mechaly; Jonathan M Monk; Ana L T Nascimento; Karen E Nelson; Bernhard Palsson; Sharon J Peacock; Mathieu Picardeau; Jessica N Ricaldi; Janjira Thaipandungpanit; Elsio A Wunder; X Frank Yang; Jun-Jie Zhang; Joseph M Vinetz
Journal:  PLoS Negl Trop Dis       Date:  2016-02-18

5.  Unity in variety--the pan-genome of the Chlamydiae.

Authors:  Astrid Collingro; Patrick Tischler; Thomas Weinmaier; Thomas Penz; Eva Heinz; Robert C Brunham; Timothy D Read; Patrik M Bavoil; Konrad Sachse; Simona Kahane; Maureen G Friedman; Thomas Rattei; Garry S A Myers; Matthias Horn
Journal:  Mol Biol Evol       Date:  2011-06-20       Impact factor: 16.240

6.  Crystal structure of the protealysin precursor: insights into propeptide function.

Authors:  Ilya V Demidyuk; Tania Yu Gromova; Konstantin M Polyakov; William R Melik-Adamyan; Inna P Kuranova; Sergey V Kostrov
Journal:  J Biol Chem       Date:  2009-11-13       Impact factor: 5.157

7.  Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro.

Authors:  Ying-Chih Chi; Jeremy T Rahkola; Agnieszka A Kendrick; Michael J Holliday; Natasia Paukovich; Thomas S Roberts; Edward N Janoff; Elan Z Eisenmesser
Journal:  Protein Sci       Date:  2017-02-23       Impact factor: 6.725

8.  A comprehensive transcriptome and immune-gene repertoire of the lepidopteran model host Galleria mellonella.

Authors:  Heiko Vogel; Boran Altincicek; Gernot Glöckner; Andreas Vilcinskas
Journal:  BMC Genomics       Date:  2011-06-11       Impact factor: 3.969

Review 9.  The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock.

Authors:  Caitlin W Hicks; Xizhong Cui; Daniel A Sweeney; Yan Li; Amisha Barochia; Peter Q Eichacker
Journal:  Toxins (Basel)       Date:  2011-09-20       Impact factor: 4.546

10.  Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.

Authors:  Cansu Kaya; Isabell Walter; Samir Yahiaoui; Asfandyar Sikandar; Alaa Alhayek; Jelena Konstantinović; Andreas M Kany; Jörg Haupenthal; Jesko Köhnke; Rolf W Hartmann; Anna K H Hirsch
Journal:  Angew Chem Int Ed Engl       Date:  2021-12-13       Impact factor: 16.823

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.