Literature DB >> 19152505

The function of ROCO proteins in health and disease.

Patrick A Lewis1.   

Abstract

The ROCO family of multidomain proteins extends across the eukaryotes, and has been implicated in numerous cellular processes. Following the description of mutations causing PD (Parkinson's disease) in a human representative of the ROCO family, LRRK2 (leucine-rich repeat kinase 2), a great deal of research has been carried out into these proteins. This review examines the published data regarding the roles the ROCO proteins are thought to play in cell processes, and how the structure and domain organization of these proteins relates to their function.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19152505     DOI： 10.1042/BC20080053

Source DB:  PubMed          Journal:  Biol Cell        ISSN： 0248-4900            Impact factor:   4.458


  24 in total

1.  The ROCO kinase QkgA is necessary for proliferation inhibition by autocrine signals in Dictyostelium discoideum.

Authors:  Jonathan E Phillips; Richard H Gomer
Journal:  Eukaryot Cell       Date:  2010-08-13

2.  Models for LRRK2-Linked Parkinsonism.

Authors:  Tianxia Li; Dejun Yang; Sarah Sushchky; Zhaohui Liu; Wanli W Smith
Journal:  Parkinsons Dis       Date:  2011-04-07

3.  MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.

Authors:  Chutima Kumkhaek; Wulin Aerbajinai; Wenli Liu; Jianqiong Zhu; Naoya Uchida; Roger Kurlander; Matthew M Hsieh; John F Tisdale; Griffin P Rodgers
Journal:  Blood       Date:  2013-01-17       Impact factor: 22.113

4.  Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate.

Authors:  Jean-Marc Taymans; Fangye Gao; Veerle Baekelandt
Journal:  J Vis Exp       Date:  2013-09-18       Impact factor: 1.355

Review 5.  Recent advances in Parkinson’s disease genetics.

Authors:  Steven Lubbe; Huw R Morris
Journal:  J Neurol       Date:  2014-02       Impact factor: 4.849

6.  Assaying the kinase activity of LRRK2 in vitro.

Authors:  Patrick A Lewis
Journal:  J Vis Exp       Date:  2012-01-18       Impact factor: 1.355

7.  Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy.

Authors:  Simon Meyer; Sabine Böhme; André Krüger; Heinz-Jürgen Steinhoff; Johann P Klare; Alfred Wittinghofer
Journal:  PLoS Biol       Date:  2009-10-06       Impact factor: 8.029

8.  Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.

Authors:  Laura Civiero; Renée Vancraenenbroeck; Elisa Belluzzi; Alexandra Beilina; Evy Lobbestael; Lauran Reyniers; Fangye Gao; Ivan Micetic; Marc De Maeyer; Luigi Bubacco; Veerle Baekelandt; Mark R Cookson; Elisa Greggio; Jean-Marc Taymans
Journal:  PLoS One       Date:  2012-08-29       Impact factor: 3.240

9.  GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.

Authors:  Joseph D Jebelli; Sybille Dihanich; Laura Civiero; Claudia Manzoni; Elisa Greggio; Patrick A Lewis
Journal:  Sci Rep       Date:  2012-09-26       Impact factor: 4.379

10.  Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.

Authors:  Lauran Reyniers; Maria Grazia Del Giudice; Laura Civiero; Elisa Belluzzi; Evy Lobbestael; Alexandra Beilina; Giorgio Arrigoni; Rita Derua; Etienne Waelkens; Yan Li; Claudia Crosio; Ciro Iaccarino; Mark R Cookson; Veerle Baekelandt; Elisa Greggio; Jean-Marc Taymans
Journal:  J Neurochem       Date:  2014-07-14       Impact factor: 5.372
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.