Literature DB >> 19152392

Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors.

Jared K Nelson1, Sidsel U Frølund, Dennis B Tikhonov, Anders S Kristensen, Kristian Strømgaard.   

Abstract

More discerning than the parent: Analogues of the polyamine toxin argiotoxin 636 (shown docked in the ion channel of an ionotropic glutamate (iGlu) receptor; N blue, O red) distinguish subtypes of iGlu receptors. Depending on which of the two internal amine groups is replaced with a methylene group, the analogue inhibits one or other of two receptor subtypes as potently as the natural compound, which itself inhibits both subtypes nonselectively.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19152392     DOI： 10.1002/anie.200805426

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  6 in total

Review 1.  Glutamate receptor pores.

Authors:  James E Huettner
Journal:  J Physiol       Date:  2014-05-06       Impact factor: 5.182

2.  Binding of ArgTX-636 in the NMDA receptor ion channel.

Authors:  Mette H Poulsen; Jacob Andersen; Rune Christensen; Kasper B Hansen; Stephen F Traynelis; Kristian Strømgaard; Anders Skov Kristensen
Journal:  J Mol Biol       Date:  2014-05-24       Impact factor: 5.469

Review 3.  Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.

Authors:  Kasper B Hansen; Lonnie P Wollmuth; Derek Bowie; Hiro Furukawa; Frank S Menniti; Alexander I Sobolevsky; Geoffrey T Swanson; Sharon A Swanger; Ingo H Greger; Terunaga Nakagawa; Chris J McBain; Vasanthi Jayaraman; Chian-Ming Low; Mark L Dell'Acqua; Jeffrey S Diamond; Chad R Camp; Riley E Perszyk; Hongjie Yuan; Stephen F Traynelis
Journal:  Pharmacol Rev       Date:  2021-10       Impact factor: 18.923

4.  Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin.

Authors:  Mette H Poulsen; Simon Lucas; Kristian Strømgaard; Anders S Kristensen
Journal:  Neurochem Res       Date:  2014-02-22       Impact factor: 3.996

5.  The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2.

Authors:  Ahmed H Ahmed; Makoto Hamada; Tetsuro Shinada; Yasufumi Ohfune; Laksiri Weerasinghe; Philip P Garner; Robert E Oswald
Journal:  J Biol Chem       Date:  2012-10-17       Impact factor: 5.157

6.  Phevamine A, a small molecule that suppresses plant immune responses.

Authors:  Erinn M O'Neill; Tatiana S Mucyn; Jon B Patteson; Omri M Finkel; Eui-Hwan Chung; Joshua A Baccile; Elisabetta Massolo; Frank C Schroeder; Jeffery L Dangl; Bo Li
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-20       Impact factor: 11.205
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.