Literature DB >> 19151327

Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans.

Petra Spröte1, Axel A Brakhage, Michael J Hynes.   

Abstract

Peroxisomal localization of the third enzyme of the penicillin biosynthesis pathway of Aspergillus nidulans, acyl-coenzyme A:IPN acyltransferase (IAT), is mediated by its atypical peroxisomal targeting signal 1 (PTS1). However, mislocalization of IAT by deletion of either its PTS1 or of genes encoding proteins involved in peroxisome formation or transport does not completely abolish penicillin biosynthesis. This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum.

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Year:  2009        PMID： 19151327      PMCID： PMC2653248          DOI： 10.1128/EC.00374-08

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  23 in total

1.  Multiple sequence alignment with the Clustal series of programs.

Authors:  Ramu Chenna; Hideaki Sugawara; Tadashi Koike; Rodrigo Lopez; Toby J Gibson; Desmond G Higgins; Julie D Thompson
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

2.  Involvement of microbodies in penicillin biosynthesis.

Authors:  W H Müller; R A Bovenberg; M H Groothuis; F Kattevilder; E B Smaal; L H Van der Voort; A J Verkleij
Journal:  Biochim Biophys Acta       Date:  1992-04-22

3.  Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster.

Authors:  Petra Spröte; Michael J Hynes; Peter Hortschansky; Ekaterina Shelest; Daniel H Scharf; Sandra M Wolke; Axel A Brakhage
Journal:  Mol Microbiol       Date:  2008-10       Impact factor: 3.501

4.  Assessment of the microbody luminal pH in the filamentous fungus Penicillium chrysogenum.

Authors:  Ted R van der Lende; Pieter Breeuwer; Tjakko Abee; Wil N Konings; Arnold J M Driessen
Journal:  Biochim Biophys Acta       Date:  2002-04-03

5.  Development of a high-frequency transforming vector for Aspergillus nidulans.

Authors:  D J Ballance; G Turner
Journal:  Gene       Date:  1985       Impact factor: 3.688

6.  Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli.

Authors:  M B Tobin; M D Fleming; P L Skatrud; J R Miller
Journal:  J Bacteriol       Date:  1990-10       Impact factor: 3.490

7.  Isolation of Penicillium chrysogenum PEX1 and PEX6 encoding AAA proteins involved in peroxisome biogenesis.

Authors:  J A Kiel; R E Hilbrands; R A Bovenberg; M Veenhuis
Journal:  Appl Microbiol Biotechnol       Date:  2000-08       Impact factor: 4.813

8.  Saccharomyces cerevisiae acyl-CoA oxidase follows a novel, non-PTS1, import pathway into peroxisomes that is dependent on Pex5p.

Authors:  Andre T J Klein; Marlene van den Berg; Gina Bottger; Henk F Tabak; Ben Distel
Journal:  J Biol Chem       Date:  2002-04-19       Impact factor: 5.157

9.  The peroxisomal lumen in Saccharomyces cerevisiae is alkaline.

Authors:  Carlo W T van Roermund; Mark de Jong; Lodewijk IJlst; Jan van Marle; Tobias B Dansen; Ronald J A Wanders; Hans R Waterham
Journal:  J Cell Sci       Date:  2004-08-15       Impact factor: 5.285

10.  Penicillium chrysogenum Pex5p mediates differential sorting of PTS1 proteins to microbodies of the methylotrophic yeast Hansenula polymorpha.

Authors:  Jan A K W Kiel; Marco van den Berg; Roel A L Bovenberg; Ida J van der Klei; Marten Veenhuis
Journal:  Fungal Genet Biol       Date:  2004-07       Impact factor: 3.495
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  14 in total

Review 1.  Role of peroxisomes in the biosynthesis and secretion of β-lactams and other secondary metabolites.

Authors:  Juan-Francisco Martín; Ricardo V Ullán; Carlos García-Estrada
Journal:  J Ind Microbiol Biotechnol       Date:  2011-12-11       Impact factor: 3.346

Review 2.  The peroxisome: an update on mysteries.

Authors:  Markus Islinger; Sandra Grille; H Dariush Fahimi; Michael Schrader
Journal:  Histochem Cell Biol       Date:  2012-03-14       Impact factor: 4.304

Review 3.  Spatial and temporal control of fungal natural product synthesis.

Authors:  Fang Yun Lim; Nancy P Keller
Journal:  Nat Prod Rep       Date:  2014-10       Impact factor: 13.423

4.  Peroxisomes are required for efficient penicillin biosynthesis in Penicillium chrysogenum.

Authors:  Wiebe H Meijer; Loknath Gidijala; Susan Fekken; Jan A K W Kiel; Marco A van den Berg; Romeo Lascaris; Roel A L Bovenberg; Ida J van der Klei
Journal:  Appl Environ Microbiol       Date:  2010-07-02       Impact factor: 4.792

Review 5.  Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes.

Authors:  Ludmila V Roze; Anindya Chanda; John E Linz
Journal:  Fungal Genet Biol       Date:  2010-05-16       Impact factor: 3.495

6.  A key role for vesicles in fungal secondary metabolism.

Authors:  Anindya Chanda; Ludmila V Roze; Suil Kang; Katherine A Artymovich; Glenn R Hicks; Natasha V Raikhel; Ana M Calvo; John E Linz
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-04       Impact factor: 11.205

7.  Membrane curvature during peroxisome fission requires Pex11.

Authors:  Łukasz Opaliński; Jan A K W Kiel; Chris Williams; Marten Veenhuis; Ida J van der Klei
Journal:  EMBO J       Date:  2010-11-26       Impact factor: 11.598

Review 8.  The significance of peroxisomes in secondary metabolite biosynthesis in filamentous fungi.

Authors:  Magdalena Bartoszewska; Lukasz Opaliński; Marten Veenhuis; Ida J van der Klei
Journal:  Biotechnol Lett       Date:  2011-06-10       Impact factor: 2.461

9.  An engineered yeast efficiently secreting penicillin.

Authors:  Loknath Gidijala; Jan A K W Kiel; Rutger D Douma; Reza M Seifar; Walter M van Gulik; Roel A L Bovenberg; Marten Veenhuis; Ida J van der Klei
Journal:  PLoS One       Date:  2009-12-15       Impact factor: 3.240

10.  Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum.

Authors:  Jon Menke; Jakob Weber; Karen Broz; H Corby Kistler
Journal:  PLoS One       Date:  2013-05-07       Impact factor: 3.240
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