| Literature DB >> 19148914 |
Thomas Kurpiers1, Henning D Mootz.
Abstract
The light-induced formation of a covalent bond between an alkene group and a tetrazole moiety has been used for the selective labeling of proteins in vitro and in live cells. This bioorthogonal ligation initiated by brief irradiation with UV light leads to a fluorescent pyrazoline adduct (see scheme).Entities:
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Year: 2009 PMID: 19148914 DOI: 10.1002/anie.200805454
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN: 1433-7851 Impact factor: 15.336