Literature DB >> 19148862

In vitro anti-influenza viral activities of constituents from Caesalpinia sappan.

Ai-Lin Liu1, Shi-Hui Shu, Hai-Lin Qin, Simon Ming Yuen Lee, Yi-Tao Wang, Guan-Hua Du.   

Abstract

Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 microg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 microg/mL, respectively.

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Year:  2009        PMID： 19148862     DOI： 10.1055/s-0028-1112208

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  19 in total

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Journal:  BMC Complement Altern Med       Date:  2015-04-22       Impact factor: 3.659

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Journal:  PLoS One       Date:  2014-10-02       Impact factor: 3.240

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