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Literature DB >> 19147696

Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells.

Bingsen Xu, Kexiong Zhang, Yingqun Huang.

Abstract

Lin28 is highly expressed in human and mouse embryonic stem (ES) cells. Here, we show that in mouse ES cells, specific repression of Lin28 results in decreased cell proliferation, while overexpression of Lin28 accelerates cell proliferation. Further, Lin28 associates specifically with ribonucleoprotein particles containing mRNAs for cyclins A and B and cdk4. Importantly, changes in Lin28 levels lead to corresponding changes in the levels of these proteins, and sequences from the 3' untranslated regions of cyclin B and cdk4 mRNAs exhibit stimulatory effects on translation of reporter genes in a Lin28-dependent fashion. Thus, we postulate that Lin28 may play a role in the regulation of translation of genes important for the growth and maintenance of pluripotent cells.

Entities: Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19147696 PMCID： PMC2657009 DOI： 10.1261/rna.1368009

Source DB: PubMed Journal: RNA ISSN： 1355-8382 Impact factor: 4.942

19 in total

1. Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase.

Authors: Klaus A Becker; Prachi N Ghule; Jaclyn A Therrien; Jane B Lian; Janet L Stein; Andre J van Wijnen; Gary S Stein
Journal: J Cell Physiol Date: 2006-12 Impact factor: 6.384

2. Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules.

Authors: Erica Balzer; Eric G Moss
Journal: RNA Biol Date: 2007-04-30 Impact factor: 4.652

3. Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency.

Authors: Anna Polesskaya; Sylvain Cuvellier; Irina Naguibneva; Arnaud Duquet; Eric G Moss; Annick Harel-Bellan
Journal: Genes Dev Date: 2007-05-01 Impact factor: 11.361

4. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells.

Authors: Hiroko Fujii-Yamamoto; Jung Min Kim; Ken-ichi Arai; Hisao Masai
Journal: J Biol Chem Date: 2005-01-19 Impact factor: 5.157

Review 5. Cell cycle control of embryonic stem cells.

Authors: Josephine White; Stephen Dalton
Journal: Stem Cell Rev Date: 2005 Impact factor: 5.739

6. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.

Authors: E G Moss; R C Lee; V Ambros
Journal: Cell Date: 1997-03-07 Impact factor: 41.582

7. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.

Authors: Shobha Vasudevan; Joan A Steitz
Journal: Cell Date: 2007-03-23 Impact factor: 41.582

Review 8. Cell-specific responses to loss of cyclin-dependent kinases.

Authors: C Berthet; P Kaldis
Journal: Oncogene Date: 2007-02-05 Impact factor: 9.867

9. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.

Authors: Inha Heo; Chirlmin Joo; Jun Cho; Minju Ha; Jinju Han; V Narry Kim
Journal: Mol Cell Date: 2008-10-24 Impact factor: 17.970

10. Temporally regulated expression of Lin-28 in diverse tissues of the developing mouse.

Authors: Dong Hua Yang; Eric G Moss
Journal: Gene Expr Patterns Date: 2003-12 Impact factor: 1.224

100 in total

1. RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation.

Authors: Elisa Närvä; Nelly Rahkonen; Maheswara Reddy Emani; Riikka Lund; Juha-Pekka Pursiheimo; Juuso Nästi; Reija Autio; Omid Rasool; Konstantin Denessiouk; Harri Lähdesmäki; Anjana Rao; Riitta Lahesmaa
Journal: Stem Cells Date: 2012-03 Impact factor: 6.277

2. Regulation of cell cycle of hepatocellular carcinoma by NF90 through modulation of cyclin E1 mRNA stability.

Authors: W Jiang; H Huang; L Ding; P Zhu; H Saiyin; G Ji; J Zuo; D Han; Y Pan; D Ding; X Ma; Y Zhang; J Wu; Q Yi; J O Liu; H Huang; Y Dang; L Yu
Journal: Oncogene Date: 2014-11-17 Impact factor: 9.867

Review 3. Cancer models in Caenorhabditis elegans.

Authors: Natalia V Kirienko; Kumaran Mani; David S Fay
Journal: Dev Dyn Date: 2010-05 Impact factor: 3.780

4. Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.

Authors: Kearney T W Gunsalus; Matthew P Wagoner; Kassondra Meyer; Wyatt B Potter; Barry Schoenike; Soyoung Kim; Caroline M Alexander; Andreas Friedl; Avtar Roopra
Journal: Cancer Res Date: 2012-04-24 Impact factor: 12.701

Review 5. Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells.

Authors: Sunil K Mallanna; Angie Rizzino
Journal: Dev Biol Date: 2010-05-15 Impact factor: 3.582