| Literature DB >> 19146825 |
Francesco Oliva1, Loredana Zocchi, Andrea Codispoti, Eleonora Candi, Monica Celi, Gerry Melino, Nicola Maffulli, Umberto Tarantino.
Abstract
The ethiopathogenesis of rotator cuff disease remains poorly understood. Many studies advocate the importance of extra cellular matrix for the homeostasis of connective tissue. Transglutaminase enzymes family has been studied in the context of connective tissue formation and stabilisation. Here, we investigated transglutaminases expression pattern in biopsies of normal and injured supraspinatus tendons of human shoulders and in the Achilles tendons of transglutaminase 2 knock-out and wild-type mice. Our results show that different transglutaminase family members are differentially expressed in human and mouse tendons, and that transglutaminase 2 is down-regulated at mRNA and protein levels upon human supraspinatus tendon ruptures.Entities:
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Year: 2009 PMID： 19146825 DOI： 10.1016/j.bbrc.2008.12.188
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575