| Literature DB >> 19146417 |
Berthold Wroblowski1, Mark J Wigglesworth, Philip G Szekeres, Graham D Smith, Shahzad S Rahman, Neville H Nicholson, Alison I Muir, Adrian Hall, Jag P Heer, Stephen L Garland, William J Coates.
Abstract
The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain. Here we describe the discovery and optimization of a small molecule agonist and initial docking studies of this ligand into the receptor in order to provide a suitable lead and tool compound for the elucidation of the physiological function of the receptor.Entities:
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Year: 2009 PMID： 19146417 DOI： 10.1021/jm800962k
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446