Literature DB >> 19146386

LiOAc-catalyzed chemoselective deprotection of aryl silyl ethers under mild conditions.

Bing Wang1, Hui-Xia Sun, Zhi-Hua Sun.   

Abstract

An efficient and chemoselective deprotection protocol for aryl silyl ethers using LiOAc as a bifunctional Lewis acid-Lewis base catalyst was described. Acetates, epoxides, and aliphatic silyl ethers were preserved, whereas aryl TBS and TBDPS ethers can be differentiated.

Entities:  

Year:  2009        PMID： 19146386     DOI： 10.1021/jo802472s

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  KHF2, a mild and selective desilylating agent for phenol t-butyldimethylsilyl (TBDMS) ethers.

Authors:  Mahesh K Lakshman; Fatou A Tine; Tashrique A Khandaker; Vikram Basava; Nana B Agyemang; Michael S A Benavidez; Marikone Gaši; Lisa Guerrera; Barbara Zajc
Journal:  Synlett       Date:  2016-11-17       Impact factor: 2.454

2.  Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload.

Authors:  Arnaud C Tiberghien; Jean-Noel Levy; Luke A Masterson; Neki V Patel; Lauren R Adams; Simon Corbett; David G Williams; John A Hartley; Philip W Howard
Journal:  ACS Med Chem Lett       Date:  2016-05-24       Impact factor: 4.345

3.  An Expedient Method for the Umpolung Coupling of Enols with Heteronucleophiles.

Authors:  Víctor García-Vázquez; Alba Carretero Cerdán; Amparo Sanz-Marco; Enrique Gómez-Bengoa; Belén Martín-Matute
Journal:  Chemistry       Date:  2022-06-17       Impact factor: 5.020
  3 in total

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