Literature DB >> 19145355

Effects of synthetic and plant-derived selective modulators of estrogen receptors on depression-like behavior of female rats.

N S Sapronov1, S B Kasakova.   

Abstract

Effects of chronic (for 14 days) intramuscular injections of tamoxifen (10 mg/kg), klimadynon (Cimicifuga extract; 20 mg/kg), and genistein (10 mg/kg) on depression-like state were studied in female rats under conditions of natural fluctuations of blood estrogen levels and ovariectomy. Chronic tamoxifen caused a pronounced depression, while chronic klimadynon and genistein exhibited a pronounced antidepressant effect in intact and ovariectomized rats.

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Year:  2008        PMID： 19145355     DOI： 10.1007/s10517-008-0210-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  6 in total

1.  Treatment with phytoestrogens for depressive symptoms in late-onset schizophrenia:a case report.

Authors:  Gopalkumar Rakesh; Naren P Rao; Ganesan Venkatasubramanian; Rishikesh V Behere; Shivarama Varambally; Bangalore N Gangadhar
Journal:  Prim Care Companion CNS Disord       Date:  2011

2.  The interaction of dietary isoflavones and estradiol replacement on behavior and brain-derived neurotrophic factor in the ovariectomized rat.

Authors:  Ashley L Russell; Jamie Moran Grimes; Darwin O Larco; Danette F Cruthirds; Joanna Westerfield; Lawren Wooten; Margaret Keil; Michael J Weiser; Michael R Landauer; Robert J Handa; T John Wu
Journal:  Neurosci Lett       Date:  2017-01-08       Impact factor: 3.046

3.  Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women.

Authors:  Bruce P Burnett; Lakshmi Pillai; Alessandra Bitto; Francesco Squadrito; Robert M Levy
Journal:  Int J Womens Health       Date:  2011-05-09

4.  The bone-protective effect of genistein in the animal model of bilateral ovariectomy: roles of phytoestrogens and PTH/PTHR1 against post-menopausal osteoporosis.

Authors:  Qing Miao; Jing-Ge Li; Shan Miao; Nan Hu; Jin Zhang; Song Zhang; Yan-Hua Xie; Jian-Bo Wang; Si-Wang Wang
Journal:  Int J Mol Sci       Date:  2011-12-22       Impact factor: 5.923

5.  The effects and possible mechanisms of puerarin to treat endometriosis model rats.

Authors:  Jin Yu; Li Zhao; Danying Zhang; Dongxia Zhai; Wei Shen; Lingling Bai; Yiqun Liu; Zailong Cai; Ji Li; Chaoqin Yu
Journal:  Evid Based Complement Alternat Med       Date:  2015-03-01       Impact factor: 2.629

6.  Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study.

Authors:  Gaurav Gupta; Tay Jia Jia; Lim Yee Woon; Dinesh Kumar Chellappan; Mayuren Candasamy; Kamal Dua
Journal:  Adv Pharmacol Sci       Date:  2015-11-22
  6 in total

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