OBJECTIVE: Current methodologies for outcome assessment of coiled cerebral aneurysms are based on rough estimations. The aim of this study was to develop a system of quantitative analysis for objective and accurate assessment of the outcome of cerebral aneurysms treated with coil embolization. METHODS: The quantitative analysis system is based on a concept of a perfect vessel tube and compartmentalized analysis of a coiled aneurysm. Based on the volumetric data of 3-dimensional radiographic angiography of the aneurysm and its associated parent vessel, a 2-step volume extraction method, including a global thresholding method and an augmented vessel method, is used for volume calculation. The coiled aneurysm (A) is compartmentalized into 2 volumetric components for quantitative analysis: 1) the volume of the coil mass (C), and 2) the volume of the uncoiled neck of the aneurysm (N). Changes in the volumetric data of the compartments A, C, and N at the time of follow-up provide a basis for outcome analysis. To test the clinical applicability of the system, the volumetric data for 21 consecutive cases of cerebral aneurysms in which a residual or recurrent cavity at the neck region was noted at the time of the 6-month follow-up evaluation were assessed with the aneurysm-coil mass-neck (ACN) outcome assessment system. RESULTS: The results of the outcome analysis of the 21 cases according to the ACN system correlated well with angiographic assessment of treatment outcome. CONCLUSION: The ACN outcome assessment system is a useful diagnostic instrument for objective and accurate assessment of the outcome of cerebral aneurysms treated with coil embolization.
OBJECTIVE: Current methodologies for outcome assessment of coiled cerebral aneurysms are based on rough estimations. The aim of this study was to develop a system of quantitative analysis for objective and accurate assessment of the outcome of cerebral aneurysms treated with coil embolization. METHODS: The quantitative analysis system is based on a concept of a perfect vessel tube and compartmentalized analysis of a coiled aneurysm. Based on the volumetric data of 3-dimensional radiographic angiography of the aneurysm and its associated parent vessel, a 2-step volume extraction method, including a global thresholding method and an augmented vessel method, is used for volume calculation. The coiled aneurysm (A) is compartmentalized into 2 volumetric components for quantitative analysis: 1) the volume of the coil mass (C), and 2) the volume of the uncoiled neck of the aneurysm (N). Changes in the volumetric data of the compartments A, C, and N at the time of follow-up provide a basis for outcome analysis. To test the clinical applicability of the system, the volumetric data for 21 consecutive cases of cerebral aneurysms in which a residual or recurrent cavity at the neck region was noted at the time of the 6-month follow-up evaluation were assessed with the aneurysm-coil mass-neck (ACN) outcome assessment system. RESULTS: The results of the outcome analysis of the 21 cases according to the ACN system correlated well with angiographic assessment of treatment outcome. CONCLUSION: The ACN outcome assessment system is a useful diagnostic instrument for objective and accurate assessment of the outcome of cerebral aneurysms treated with coil embolization.
Authors: Jennifer N Rodriguez; Ya-Jen Yu; Matthew W Miller; Thomas S Wilson; Jonathan Hartman; Fred J Clubb; Brandon Gentry; Duncan J Maitland Journal: Ann Biomed Eng Date: 2011-11-19 Impact factor: 3.934
Authors: C Sherif; S Marbacher; J Fandino; S Erhardt; V Neuschmelting; M Killer; G Mach; L Remonda Journal: AJNR Am J Neuroradiol Date: 2011-12-22 Impact factor: 3.825