James J Corbett1. 1. Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. jcorbett@neurology.umsmed.edu
Abstract
BACKGROUND: Case reports of familial idiopathic intracranial hypertension (IIH) have appeared sporadically and infrequently. METHODS: We reviewed the medical records of all patients with IIH seen at our institution to identify the number of familial cases. RESULTS: Out of a cohort of 237 patients with IIH, we identified 27 members (25 women and 2 men) from 11 families, with IIH usually self-reported or reported by the index case. In 7 of the 11 families, the relationship was parent to child; in 4, it was sibling. Obesity was present in 85% of the family members. CONCLUSIONS: Familial IIH appears to be more common than reported previously. A systematic evaluation of first-degree relatives may help to identify more cases. A study of the patterns of inheritance and associated co-morbidities may result in better understanding of the genetic issues with this disorder.
BACKGROUND: Case reports of familial idiopathic intracranial hypertension (IIH) have appeared sporadically and infrequently. METHODS: We reviewed the medical records of all patients with IIH seen at our institution to identify the number of familial cases. RESULTS: Out of a cohort of 237 patients with IIH, we identified 27 members (25 women and 2 men) from 11 families, with IIH usually self-reported or reported by the index case. In 7 of the 11 families, the relationship was parent to child; in 4, it was sibling. Obesity was present in 85% of the family members. CONCLUSIONS: Familial IIH appears to be more common than reported previously. A systematic evaluation of first-degree relatives may help to identify more cases. A study of the patterns of inheritance and associated co-morbidities may result in better understanding of the genetic issues with this disorder.
Authors: Michael Wall; Mark J Kupersmith; Karl D Kieburtz; James J Corbett; Steven E Feldon; Deborah I Friedman; David M Katz; John L Keltner; Eleanor B Schron; Michael P McDermott Journal: JAMA Neurol Date: 2014-06 Impact factor: 18.302
Authors: Markus H Kuehn; Rajashree Mishra; Benjamin E Deonovic; Kimberly N Miller; Shana E McCormack; Grant T Liu; Mark J Kupersmith; Michael Wall Journal: J Neuroophthalmol Date: 2019-03 Impact factor: 3.042