OBJECTIVE: We aimed to develop a simple clinically useful prediction rule for early-onset recurrent preeclampsia and/or HELLP syndrome. METHODS: Women with previous early-onset preeclampsia and/or HELLP, enrolled between 1996 and 2007, and a subsequent ongoing pregnancy were included. Prepregnant cardiovascular, metabolic, renal, and clotting parameters were evaluated as potential predictors for recurrent disease by logistic regression analysis. RESULTS: Early-onset preeclampsia and/or HELLP recurred in 16 (9%) of 186 next pregnancies. The prediction model included high-density lipoprotein (mmol/L) and 24-hour urinary total protein excretion (mg/mmol creatinine). The receiver operating characteristic area was 0.77 (95% confidence interval: 0.68-0.87). Predictive sensitivity and specificity were 94% (69%-99%) and 53% (45%-60%), respectively. Nearly 50% of the women could be classified as having <1% risk of recurrent early-onset disease. CONCLUSIONS: The prediction rule identified, with clinically relevant predictive capacity, those women at very low risk for recurrent early-onset disease.
OBJECTIVE: We aimed to develop a simple clinically useful prediction rule for early-onset recurrent preeclampsia and/or HELLP syndrome. METHODS:Women with previous early-onset preeclampsia and/or HELLP, enrolled between 1996 and 2007, and a subsequent ongoing pregnancy were included. Prepregnant cardiovascular, metabolic, renal, and clotting parameters were evaluated as potential predictors for recurrent disease by logistic regression analysis. RESULTS: Early-onset preeclampsia and/or HELLP recurred in 16 (9%) of 186 next pregnancies. The prediction model included high-density lipoprotein (mmol/L) and 24-hour urinary total protein excretion (mg/mmol creatinine). The receiver operating characteristic area was 0.77 (95% confidence interval: 0.68-0.87). Predictive sensitivity and specificity were 94% (69%-99%) and 53% (45%-60%), respectively. Nearly 50% of the women could be classified as having <1% risk of recurrent early-onset disease. CONCLUSIONS: The prediction rule identified, with clinically relevant predictive capacity, those women at very low risk for recurrent early-onset disease.
Authors: Carmen A H Severens-Rijvers; Salwan Al-Nasiry; Annemiek Vincken; Guido Haenen; Bjorn Winkens; Chahinda Ghossein-Doha; Marc A E Spaanderman; Louis L H Peeters Journal: Gynecol Obstet Invest Date: 2019-07-29 Impact factor: 2.031
Authors: Carmen A H Severens-Rijvers; Salwan Al-Nasiry; Chahinda Ghossein-Doha; Sara Marzano; Hugo Ten Cate; Bjorn Winkens; Marc A E Spaanderman; Louis L H Peeters Journal: Gynecol Obstet Invest Date: 2016-09-20 Impact factor: 2.031
Authors: Denise H J Delahaije; Sander M J van Kuijk; Carmen D Dirksen; Simone J S Sep; Louis L Peeters; Marc E Spaanderman; Hein W Bruinse; Laura D de Wit-Zuurendonk; Joris A M van der Post; Johannes J Duvekot; Jim van Eyck; Mariëlle G van Pampus; Mark A B H M van der Hoeven; Luc J Smits Journal: BMC Pregnancy Childbirth Date: 2010-10-11 Impact factor: 3.007