Literature DB >> 1914415

Effect of interleukin-1 on hyaluronate synthesis by synovial fibroblastic cells.

Y T Konttinen1, H Saari, D C Nordström.   

Abstract

Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro. In the present study the degree of polymerization of such HA was studied using HPLC (high performance liquid chromatography) with a size exclusion column combined with 125I-HABP assay used to measure the HA concentration in various HA molecular weight fractions separated using HPLC. IL-1 stimulated HA was more polydisperse than that produced by resting fibroblasts with a molecular weight varying from more than 4 x 10(6) daltons to less than 7.1 x 10(3) daltons. This IL-1 effect may contribute to the low molecular weight HA produced by freshly explanted arthritic synovial tissue and to the low viscosity of arthritic synovial fluid in vivo.

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Year:  1991        PMID： 1914415     DOI： 10.1007/bf02207654

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  27 in total

1.  Cellular origin of hyaluronateprotein in human synovial membrane.

Authors:  S Blau; R Janis; D Hamerman; J Sandson
Journal:  Science       Date:  1965-10-15       Impact factor: 47.728

2.  In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.

Authors:  T R Chen
Journal:  Exp Cell Res       Date:  1977-02       Impact factor: 3.905

3.  Human recombinant interleukin-1 beta stimulates glycosaminoglycan production in human synovial fibroblast cultures.

Authors:  I Yaron; F A Meyer; J M Dayer; M Yaron
Journal:  Arthritis Rheum       Date:  1987-04

4.  Hypoxic-reperfusion injury in the inflamed human joint.

Authors:  D R Blake; P Merry; J Unsworth; B L Kidd; J M Outhwaite; R Ballard; C J Morris; L Gray; J Lunec
Journal:  Lancet       Date:  1989-02-11       Impact factor: 79.321

5.  Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies.

Authors:  L B Dahl; I M Dahl; A Engström-Laurent; K Granath
Journal:  Ann Rheum Dis       Date:  1985-12       Impact factor: 19.103

6.  Determination of concentration of hyaluronate in equine serum.

Authors:  R M Tulamo; H Saari; Y T Konttinen
Journal:  Am J Vet Res       Date:  1990-05       Impact factor: 1.156

7.  Effect of oxygen-derived free radicals on hyaluronic acid.

Authors:  R A Greenwald; W W Moy
Journal:  Arthritis Rheum       Date:  1980-04

8.  Determination of synovial fluid hyaluronate concentration and polymerisation by high performance liquid chromatography.

Authors:  H Saari; Y T Konttinen
Journal:  Ann Rheum Dis       Date:  1989-07       Impact factor: 19.103

9.  Stimulation of the hyaluronic acid levels of human synovial fibroblasts by recombinant human tumor necrosis factor alpha, tumor necrosis factor beta (lymphotoxin), interleukin-1 alpha, and interleukin-1 beta.

Authors:  D M Butler; G F Vitti; T Leizer; J A Hamilton
Journal:  Arthritis Rheum       Date:  1988-10

10.  The effects of synovial fluid macrophages and interleukin-1 on hyaluronic acid synthesis by normal synovial fibroblasts.

Authors:  K Pulkki
Journal:  Rheumatol Int       Date:  1986       Impact factor: 2.631
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  1 in total

1.  Jellyfish mucin may have potential disease-modifying effects on osteoarthritis.

Authors:  Naoshi Ohta; Masato Sato; Kiminori Ushida; Mami Kokubo; Takayuki Baba; Kayoko Taniguchi; Makoto Urai; Koji Kihira; Joji Mochida
Journal:  BMC Biotechnol       Date:  2009-12-08       Impact factor: 2.563
  1 in total

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