Literature DB >> 19143632

Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101.

Hans-Martin Herz1, Andreas Bergmann.   

Abstract

Class E Vps (vacuolar protein sorting) proteins are components of the ESCRTs (endosomal sorting complexes required for transport) which are required for protein sorting at the early endosome. Most of these genes have been identified and genetically characterized in yeast. Recent genetic studies in Drosophila have revealed the phenotypic consequences of loss of vps function in multicellular organisms. In the present paper, we review these studies and discuss a mechanism which may explain how loss of the human Tsg101 (tumour susceptibility gene 101), a vps23 orthologue, causes tumours.

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Year:  2009        PMID： 19143632     DOI： 10.1042/BST0370204

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  10 in total

Review 1.  JAK/STAT pathway dysregulation in tumors: a Drosophila perspective.

Authors:  Marc Amoyel; Abigail M Anderson; Erika A Bach
Journal:  Semin Cell Dev Biol       Date:  2014-03-28       Impact factor: 7.727

2.  UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila.

Authors:  Gina Lee; Chengyu Liang; Gihyun Park; Cholsoon Jang; Jae U Jung; Jongkyeong Chung
Journal:  Dev Biol       Date:  2011-06-25       Impact factor: 3.582

3.  Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway.

Authors:  Brian S Robinson; Kenneth H Moberg
Journal:  Cell Cycle       Date:  2011-12-01       Impact factor: 4.534

Review 4.  Intercellular cooperation and competition in brain cancers: lessons from Drosophila and human studies.

Authors:  Indrayani Waghmare; Austin Roebke; Mutsuko Minata; Madhuri Kango-Singh; Ichiro Nakano
Journal:  Stem Cells Transl Med       Date:  2014-09-17       Impact factor: 6.940

5.  Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila.

Authors:  Audrey E Christiansen; Tian Ding; Andreas Bergmann
Journal:  Mech Dev       Date:  2012-06-05       Impact factor: 1.882

Review 6.  Endocytosis and intracellular trafficking of Notch and its ligands.

Authors:  Shinya Yamamoto; Wu-Lin Charng; Hugo J Bellen
Journal:  Curr Top Dev Biol       Date:  2010       Impact factor: 4.897

7.  Notch signaling activates Yorkie non-cell autonomously in Drosophila.

Authors:  Hillary K Graves; Sarah E Woodfield; Chih-Chao Yang; Georg Halder; Andreas Bergmann
Journal:  PLoS One       Date:  2012-06-05       Impact factor: 3.240

8.  Dme-Hsa Disease Database (DHDD): Conserved Human Disease-Related miRNA and Their Targeting Genes in Drosophila melanogaster.

Authors:  Guanyun Wei; Lianjie Sun; Shijie Qin; Ruimin Li; Liming Chen; Ping Jin; Fei Ma
Journal:  Int J Mol Sci       Date:  2018-09-06       Impact factor: 5.923

9.  Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.

Authors:  Chloe Thomas; David Strutt
Journal:  Dev Biol       Date:  2013-10-05       Impact factor: 3.582

Review 10.  Molecular Genetics of Frontotemporal Dementia Elucidated by Drosophila Models-Defects in Endosomal⁻Lysosomal Pathway.

Authors:  Sarah E Vandal; Xiaoyue Zheng; S Tariq Ahmad
Journal:  Int J Mol Sci       Date:  2018-06-09       Impact factor: 5.923
  10 in total

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