Literature DB >> 19143053

A new MAFia in cancer.

Alain Eychène1, Nathalie Rocques, Celio Pouponnot.   

Abstract

Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer--overexpression of the large Maf genes promotes the development of multiple myeloma--they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.

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Year:  2008        PMID： 19143053     DOI： 10.1038/nrc2460

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  84 in total

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Authors:  Kenneth L Seldeen; Brian J Deegan; Vikas Bhat; David C Mikles; Caleb B McDonald; Amjad Farooq
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4.  DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

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6.  Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding.

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Journal:  J Biol Chem       Date:  2010-03-05       Impact factor: 5.157

7.  Notch signaling dynamically regulates adult β cell proliferation and maturity.

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8.  A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant.

Authors:  Sanne M M Hensen; Lonneke Heldens; Siebe T van Genesen; Ger J M Pruijn; Nicolette H Lubsen
Journal:  Cell Stress Chaperones       Date:  2013-01-16       Impact factor: 3.667

9.  KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Authors:  Amy Hansen; Stephen Henderson; Dimitrios Lagos; Leonid Nikitenko; Eve Coulter; Sinead Roberts; Fiona Gratrix; Karlie Plaisance; Rolf Renne; Mark Bower; Paul Kellam; Chris Boshoff
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Review 10.  Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases.

Authors:  Jeske J Smink; Achim Leutz
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