| Literature DB >> 1914260 |
S Uwatoko1, V J Gauthier, M Mannik.
Abstract
The autoantibodies to the collagen-like region of C1q (CLR), purified from two patients with systemic lupus erythematosus, deposited in mouse glomeruli when human C1q was present in antigen-antibody complexes in glomeruli. The immune deposits with C1q in mouse glomeruli were achieved by the administration of cationized immune complexes containing human C1q. The presented data suggest that the autoantibodies to CLR could enhance the pathogenic role of immune complexes deposited in glomeruli by binding to C1q in immune deposits. These findings may explain the association of autoantibodies to CLR with proliferative lupus nephritis.Entities:
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Year: 1991 PMID： 1914260 DOI： 10.1016/s0090-1229(05)80030-3
Source DB: PubMed Journal: Clin Immunol Immunopathol ISSN： 0090-1229