Bo Xu1, Michael Murray. 1. Geriatric Evaluation and Management Unit, St Vincent's Hospital, Melbourne, Victoria. greatbear227@hotmail.com
Abstract
BACKGROUND: Acute interstitial nephritis is a less frequently reported adverse effect of flucloxacillin compared with other well known associations such as hepatotoxicity. OBJECTIVE: This article describes the conservative management of a case of flucloxacillin induced acute renal failure, and reviews the available evidence on the treatment of drug induced acute interstitial nephritis, including the use of corticosteroids. DISCUSSION: Drug induced acute interstitial nephritis can be managed conservatively by cessation of the suspected offending drug in many cases. Referral should be made to a nephrologist, with consideration given to renal biopsy, followed by trial of corticosteroids, if renal function does not improve within 7 days of drug cessation.
BACKGROUND: Acute interstitial nephritis is a less frequently reported adverse effect of flucloxacillin compared with other well known associations such as hepatotoxicity. OBJECTIVE: This article describes the conservative management of a case of flucloxacillin induced acute renal failure, and reviews the available evidence on the treatment of drug induced acute interstitial nephritis, including the use of corticosteroids. DISCUSSION: Drug induced acute interstitial nephritis can be managed conservatively by cessation of the suspected offending drug in many cases. Referral should be made to a nephrologist, with consideration given to renal biopsy, followed by trial of corticosteroids, if renal function does not improve within 7 days of drug cessation.
Authors: Amy Legg; Niamh Meagher; Sandra A Johnson; Matthew A Roberts; Alan Cass; Marc H Scheetz; Jane Davies; Jason A Roberts; Joshua S Davis; Steven Y C Tong Journal: Clin Drug Investig Date: 2022-10-10 Impact factor: 3.580
Authors: Natasha E Holmes; J Owen Robinson; Sebastiaan J van Hal; Wendy J Munckhof; Eugene Athan; Tony M Korman; Allen C Cheng; John D Turnidge; Paul D R Johnson; Benjamin P Howden Journal: BMC Infect Dis Date: 2018-03-05 Impact factor: 3.090