Gwen S Skloot1, Clyde B Schechter2, Robin Herbert3, Jacqueline M Moline3, Stephen M Levin3, Laura E Crowley3, Benjamin J Luft4, Iris G Udasin5, Paul L Enright6. 1. Mount Sinai School of Medicine, New York, NY. Electronic address: gwen.skloot@mssm.edu. 2. Albert Einstein College of Medicine, Bronx, NY. 3. Mount Sinai School of Medicine, New York, NY. 4. Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY. 5. Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, NJ. 6. College of Public Health, the University of Arizona, Tucson, AZ.
Abstract
BACKGROUND: Multiple studies have demonstrated an initial high prevalence of spirometric abnormalities following World Trade Center (WTC) disaster exposure. We assessed prevalence of spirometric abnormalities and changes in spirometry between baseline and first follow-up evaluation in participants in the WTC Worker and Volunteer Medical Monitoring Program. We also determined the predictors of spirometric change between the two examinations. METHODS: Prebronchodilator and postbronchodilator spirometry, demographics, occupational history, smoking status, and respiratory symptoms and exposure onset were obtained at both examinations (about 3 years apart). RESULTS: At the second examination, 24.1% of individuals had abnormal spirometry findings. The predominant defect was a low FVC without obstruction (16.1%). Between examinations, the majority of individuals did not have a greater-than-expected decline in lung function. The mean declines in prebronchodilator FEV(1) and FVC were 13 mL/yr and 2 mL/yr, respectively (postbronchodilator results were similar and not reported). Significant predictors of greater average decline between examinations were lack of bronchodilator responsiveness at examination 1 and weight gain [corrected]. CONCLUSIONS: Elevated rates of spirometric abnormalities were present at both examinations, with reduced FVC most common. Although the majority had a normal decline in lung function, lack of bronchodilator response at examination 1 and weight gain were significantly associated with greater-than-normal lung function declines [corrected]. Due to the presence of spirometric abnormalities > 5 years after the disaster in many exposed individuals, longer-term monitoring of WTC responders is essential.
BACKGROUND: Multiple studies have demonstrated an initial high prevalence of spirometric abnormalities following World Trade Center (WTC) disaster exposure. We assessed prevalence of spirometric abnormalities and changes in spirometry between baseline and first follow-up evaluation in participants in the WTC Worker and Volunteer Medical Monitoring Program. We also determined the predictors of spirometric change between the two examinations. METHODS: Prebronchodilator and postbronchodilator spirometry, demographics, occupational history, smoking status, and respiratory symptoms and exposure onset were obtained at both examinations (about 3 years apart). RESULTS: At the second examination, 24.1% of individuals had abnormal spirometry findings. The predominant defect was a low FVC without obstruction (16.1%). Between examinations, the majority of individuals did not have a greater-than-expected decline in lung function. The mean declines in prebronchodilator FEV(1) and FVC were 13 mL/yr and 2 mL/yr, respectively (postbronchodilator results were similar and not reported). Significant predictors of greater average decline between examinations were lack of bronchodilator responsiveness at examination 1 and weight gain [corrected]. CONCLUSIONS: Elevated rates of spirometric abnormalities were present at both examinations, with reduced FVC most common. Although the majority had a normal decline in lung function, lack of bronchodilator response at examination 1 and weight gain were significantly associated with greater-than-normal lung function declines [corrected]. Due to the presence of spirometric abnormalities > 5 years after the disaster in many exposed individuals, longer-term monitoring of WTC responders is essential.
Authors: William N Rom; Joan Reibman; Linda Rogers; Michael D Weiden; Beno Oppenheimer; Kenneth Berger; Roberta Goldring; Denise Harrison; David Prezant Journal: Proc Am Thorac Soc Date: 2010-05
Authors: Thomas K Aldrich; Madeline Vossbrinck; Rachel Zeig-Owens; Charles B Hall; Theresa M Schwartz; William Moir; Mayris P Webber; Hillel W Cohen; Anna Nolan; Michael D Weiden; Vasilios Christodoulou; Kerry J Kelly; David J Prezant Journal: Chest Date: 2016-01-13 Impact factor: 9.410
Authors: Rafael E de la Hoz; Xiaoyu Liu; John T Doucette; Anthony P Reeves; Laura A Bienenfeld; Juan P Wisnivesky; Juan C Celedón; David A Lynch; Raúl San José Estépar Journal: Lung Date: 2018-05-24 Impact factor: 2.584
Authors: Michael D Weiden; Natalia Ferrier; Anna Nolan; William N Rom; Ashley Comfort; Jackson Gustave; Rachel Zeig-Owens; Shugi Zheng; Roberta M Goldring; Kenneth I Berger; Kaitlyn Cosenza; Roy Lee; Mayris P Webber; Kerry J Kelly; Thomas K Aldrich; David J Prezant Journal: Chest Date: 2009-10-09 Impact factor: 9.410
Authors: Thomas K Aldrich; Jackson Gustave; Charles B Hall; Hillel W Cohen; Mayris P Webber; Rachel Zeig-Owens; Kaitlyn Cosenza; Vasilios Christodoulou; Lara Glass; Fairouz Al-Othman; Michael D Weiden; Kerry J Kelly; David J Prezant Journal: N Engl J Med Date: 2010-04-08 Impact factor: 91.245
Authors: Mengling Liu; Meng Qian; Qinyi Cheng; Kenneth I Berger; Yongzhao Shao; Meredith Turetz; Angeliki Kazeros; Sam Parsia; Roberta M Goldring; Caraleess Caplan-Shaw; Maria Elena Fernandez-Beros; Michael Marmor; Joan Reibman Journal: J Occup Environ Med Date: 2012-10 Impact factor: 2.162
Authors: Xiangmeng Chen; Teng Ma; Rowena Yip; Ponni V Perumalswami; Andrea D Branch; Sara Lewis; Michael Crane; David F Yankelevitz; Claudia I Henschke Journal: Clin Imaging Date: 2019-12-12 Impact factor: 1.605