Putting the puzzle together: epidemiological and clinical clues in the etiology of eosinophilic esophagitis.

The cause of eosinophilic esophagitis remains unknown, but its epidemiology and clinical features provide pieces to the puzzle. Eosinophilic esophagitis probably emerged in the 1950s or early 1960s, has an increasing incidence, occurs in most developed countries, is related to food allergies, affects adults and children, has a strong male predominance, clusters in families, and is commonly associated with other allergic and atopic disorders. Several theories have been proposed to explain its evolution, but none has been convincingly demonstrated.