[Spatio-temporal heterogeneity of human left ventricle contractions in norm and under ischemic heart disease].

2D-ultrasonic images of the left ventricle are analyzed and spatio-temporal heterogeneity of regional wall motion is characterized quantitatively in norm and in ischemic heart disease. Negative correlation between regional heterogeneity and global ejection fraction is revealed. Regional heterogeneity is shown to increase significantly in a group of patients as compared to healthy people. Role of apex in ventricular pump function is specified. Diagnostic indicator of regional wall motion abnormality is suggested. The data allow one to challenge a new paradigm of morpho-functional organization of heart based on the functional heterogeneity of modules (segments) that compose ventricular wall and differ in biomechanical characteristics and timing of both electrical and mechanical activation.