Literature DB >> 19139241

Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.

Shi Chen1, Xiangzhao Mao, Yaling Shen, Yongjun Zhou, Jialiang Li, Lianrong Wang, Xinyi Tao, Liang Yang, Yuxiao Wang, Xiufen Zhou, Zixin Deng, Dongzhi Wei.   

Abstract

Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.

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Year:  2009        PMID： 19139241      PMCID： PMC2655452          DOI： 10.1128/AEM.00859-08

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  15 in total

1.  Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.

Authors:  T Brautaset; O N Sekurova; H Sletta; T E Ellingsen; A R StrŁm; S Valla; S B Zotchev
Journal:  Chem Biol       Date:  2000-06

2.  The effect of polyene macrolides on the prostate gland and canine prostatic hyperplasia.

Authors:  H W Gordon; C P Schaffner
Journal:  Proc Natl Acad Sci U S A       Date:  1968-08       Impact factor: 11.205

3.  Studies on candicidin biogenesis.

Authors:  C M Liu; L E McDaniel; C P Schaffner
Journal:  J Antibiot (Tokyo)       Date:  1972-02       Impact factor: 2.649

4.  Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.

Authors:  M V Mendes; E Recio; R Fouces; R Luiten; J F Martín; J F Aparicio
Journal:  Chem Biol       Date:  2001-07

5.  Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.

Authors:  P Caffrey; S Lynch; E Flood; S Finnan; M Oliynyk
Journal:  Chem Biol       Date:  2001-07

Review 6.  How do the polyene macrolide antibiotics affect the cellular membrane properties?

Authors:  J Bolard
Journal:  Biochim Biophys Acta       Date:  1986-12-22

7.  Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex.

Authors:  Shi Chen; Xi Huang; Xiufen Zhou; Linquan Bai; Jing He; Ki Jun Jeong; Sang Yup Lee; Zixin Deng
Journal:  Chem Biol       Date:  2003-11

8.  Effect of candicidin on cholesterol and bile acid metabolism in the rat.

Authors:  A K Singhal; E H Mosbach; C P Schaffner
Journal:  Lipids       Date:  1981-06       Impact factor: 1.880

Review 9.  Candicidin and other polyenic antifungal antibiotics.

Authors:  S A Waksman; H A Lechevalier; C P Schaffner
Journal:  Bull World Health Organ       Date:  1965       Impact factor: 9.408

Review 10.  Polyene antibiotic biosynthesis gene clusters.

Authors:  J F Aparicio; P Caffrey; J A Gil; S B Zotchev
Journal:  Appl Microbiol Biotechnol       Date:  2002-12-18       Impact factor: 4.813
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  5 in total

Review 1.  An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains.

Authors:  Yohei Iizaka; David H Sherman; Yojiro Anzai
Journal:  Appl Microbiol Biotechnol       Date:  2021-03-12       Impact factor: 4.813

Review 2.  Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

Authors:  Jeffrey D Rudolf; Chin-Yuan Chang; Ming Ma; Ben Shen
Journal:  Nat Prod Rep       Date:  2017-08-30       Impact factor: 13.423

3.  Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway.

Authors:  Martin Richter; Benjamin Busch; Keishi Ishida; Bradley S Moore; Christian Hertweck
Journal:  Chembiochem       Date:  2012-09-07       Impact factor: 3.164

Review 4.  Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes.

Authors:  Dekun Kong; Mi-Jin Lee; Shuangjun Lin; Eung-Soo Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2013-03-21       Impact factor: 3.346

5.  Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strain.

Authors:  Tingting Yao; Zengzhi Liu; Tong Li; Hui Zhang; Jing Liu; Huayue Li; Qian Che; Tianjiao Zhu; Dehai Li; Wenli Li
Journal:  Microb Cell Fact       Date:  2018-06-19       Impact factor: 5.328
  5 in total

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