| Literature DB >> 19138565 |
Abstract
Recent epidemiological and experimental data indicate that infection with helminths can protect humans from the development of allergic disorders by immunosuppressive mechanisms that involve the induction of IL-10 and/or regulatory T cells. Furthermore, helminth-derived immune modulators suppress allergic responses in mice. Trichuris suis therapy has been shown to be safe and efficacious in treating inflammatory bowel disease in humans. Has the time come to treat patients who have allergic diseases or healthy humans who are at risk of developing these diseases with helminths or helminth-derived products? Here, I discuss the pros and cons of such an approach.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19138565 DOI： 10.1016/j.it.2008.11.005
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687