Literature DB >> 19138519

Syntheses and potential anti-prostate cancer activities of ionone-based chalcones.

Jinming Zhou1, Guoyan Geng, Gerald Batist, Jian Hui Wu.   

Abstract

We report the SAR studies of 43 ionone-based chalcones that demonstrate substantial in vitro anti-proliferative activities in LNCaP, MDA-PCa-2b, 22Rv1, C4-2B and PC-3 prostate cancer cell lines. Compound 25 with an IC(50) value of 0.74 microM in LNCaP cells potently antagonizes DHT-induced transactivation of the wild type and the clinically relevant T877A, W741C and H874Y mutated androgen receptors, representing a novel chalcone as pan-antagonist of androgen receptor.

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Year:  2008        PMID： 19138519     DOI： 10.1016/j.bmcl.2008.12.089

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  New 4-maleamic acid and 4-maleamide peptidyl chalcones as potential multitarget drugs for human prostate cancer.

Authors:  Juan Rodrigues; Claudia Abramjuk; Luis Vásquez; Neira Gamboa; José Domínguez; Bianca Nitzsche; Michael Höpfner; Radostina Georgieva; Hans Bäumler; Carsten Stephan; Klaus Jung; Michael Lein; Anja Rabien
Journal:  Pharm Res       Date:  2010-12-24       Impact factor: 4.200

2.  Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth.

Authors:  Cassia S Mizuno; Shiby Paul; Nanjoo Suh; Agnes M Rimando
Journal:  Bioorg Med Chem Lett       Date:  2010-10-14       Impact factor: 2.823

3.  Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells.

Authors:  Ewelina Szliszka; Zenon P Czuba; Bogdan Mazur; Lukasz Sedek; Andrzej Paradysz; Wojciech Krol
Journal:  Int J Mol Sci       Date:  2009-12-24       Impact factor: 5.923

4.  Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants.

Authors:  Jinming Zhou; Guoyan Geng; Jian Hui Wu
Journal:  Invest New Drugs       Date:  2009-04-24       Impact factor: 3.850

5.  Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.

Authors:  Joseph K Hexum; Rodolfo Tello-Aburto; Nicholas B Struntz; Andrew M Harned; Daniel A Harki
Journal:  ACS Med Chem Lett       Date:  2012-05-11       Impact factor: 4.345

6.  Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB.

Authors:  Weiguo Liu; Jinming Zhou; Guoyan Geng; Rongtuan Lin; Jian Hui Wu
Journal:  Invest New Drugs       Date:  2013-10-23       Impact factor: 3.850

7.  (1E,4E)-1-(Thio-phen-2-yl)-5-(2,6,6-trimethyl-cyclo-hex-1-en-1-yl)penta-1,4-dien-3-one.

Authors:  Ya-Li Zhang; Liu-Fang Xiang; Peng Zou; Yi-Jun Jin; Shu-Lin Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-23

8.  CoMFA, CoMSIA, HQSAR and Molecular Docking Analysis of Ionone-based Chalcone Derivatives as Antiprostate Cancer Activity.

Authors:  R Sharma; N Dhingra; S Patil
Journal:  Indian J Pharm Sci       Date:  2016 Jan-Feb       Impact factor: 0.975

9.  Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells.

Authors:  Ewelina Szliszka; Zenon P Czuba; Bogdan Mazur; Andrzej Paradysz; Wojciech Krol
Journal:  Molecules       Date:  2010-08-04       Impact factor: 4.411

10.  Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway.

Authors:  Hongtian Zhu; Lei Tang; Chenghong Zhang; Baochu Wei; Pingrong Yang; Dian He; Lifang Zheng; Yang Zhang
Journal:  Front Pharmacol       Date:  2019-11-15       Impact factor: 5.810
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