Literature DB >> 19137520

Synthesis of unprecedented scaffold diversity.

Warren R J D Galloway1, Mónica Diáz-Gavilán, Albert Isidro-Llobet, David R Spring.   

Abstract

Building a better library: The synthesis of a library of natural-product-like small molecules with unprecedented scaffold diversity has been reported (see scheme; Ns = nosylate). The library represents a significant advancement in the capability of synthetic chemists to generate structurally diverse and complex small molecules in a rapid manner.

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Year:  2009        PMID： 19137520     DOI： 10.1002/anie.200805452

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  4 in total

1.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

2.  Diversity-oriented synthesis of macrocyclic peptidomimetics.

Authors:  Albert Isidro-Llobet; Tiffanie Murillo; Paula Bello; Agostino Cilibrizzi; James T Hodgkinson; Warren R J D Galloway; Andreas Bender; Martin Welch; David R Spring
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

3.  Tungsten anchored onto functionalized SBA-15: an efficient catalyst for diastereoselective synthesis of 2-azapyrrolizidine alkaloid scaffolds.

Authors:  Javad Safaei-Ghomi; Atefeh Bakhtiari
Journal:  RSC Adv       Date:  2019-06-24       Impact factor: 4.036

4.  iVS analysis to evaluate the impact of scaffold diversity in the binding to cellular targets relevant in cancer.

Authors:  Agostino Cilibrizzi; Giuseppe Floresta; Vincenzo Abbate; Maria Paola Giovannoni
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051
  4 in total

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