| Literature DB >> 19137519 |
Leo Leung1, Cyrille Tomassi, Katrien Van Beneden, Tine Decruy, Matthias Trappeniers, Dirk Elewaut, Yifang Gao, Tim Elliott, Aymen Al-Shamkhani, Christian Ottensmeier, Jörn M Werner, Anthony Williams, Serge Van Calenbergh, Bruno Linclau.
Abstract
The synthesis of 2',2'-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.Entities:
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Year: 2009 PMID： 19137519 DOI： 10.1002/cmdc.200800348
Source DB: PubMed Journal: ChemMedChem ISSN： 1860-7179 Impact factor: 3.466