| Literature DB >> 19136201 |
Ronald Wolf1, Christopher Voscopoulos, Jason Winston, Alif Dharamsi, Paul Goldsmith, Michele Gunsior, Barbara K Vonderhaar, Melanie Olson, Peter H Watson, Stuart H Yuspa.
Abstract
Human S100A7 (psoriasin) is considered a marker for specific stages of breast cancer. hS100A15 is almost identical to hS100A7 and difficult to discriminate. We developed specific probes to distinguish hS100A7 and hS100A15, and demonstrate their differential distribution in normal breast tissue. Further, hS100A7 and S100A15 transcripts are elevated in ER/PR negative breast cancers, but hS100A15 protein is detected in all cancer specimens while hS100A7 protein is sporadically expressed. The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers.Entities:
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Year: 2009 PMID： 19136201 PMCID： PMC2680177 DOI： 10.1016/j.canlet.2008.11.032
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679