| Literature DB >> 19135978 |
Atsushi Yamada1, Dai Suzuki, Agasa Miyazono, Kumiko Oshima, Akihide Kamiya, Baohong Zhao, Masamichi Takami, Raymond P Donnelly, Hiroyuki Itabe, Matsuo Yamamoto, Shioko Kimura, Ryutaro Kamijo.
Abstract
STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-gamma on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found that expression of SCGB3A1 was down-regulated by IFN-gamma in a time- and dose-dependent manner in the murine transformed Clara Cells (mtCC) line. IFN-gamma induced the phosphorylation of STAT1, which binds to a STAT-binding element (SBE) in the SCGB3A1 gene promoter, leading to decreased transcriptional activation of this gene.Entities:
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Year: 2009 PMID： 19135978 PMCID： PMC2792195 DOI： 10.1016/j.bbrc.2008.12.187
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575