Literature DB >> 19135970

Ionic liquids promote amyloid formation from alpha-synuclein.

Heejin Hwang1, Hyunghun Choi, Hyun-Kyung Kim, Do Hyun Jo, T Doohun Kim.   

Abstract

The slow process required for alpha-synuclein to form amyloid fibrils is a major obstacle in the development of therapeutic compounds for alpha-synuclein-related neurodegenerative diseases such as Parkinson's disease (PD). Here we have developed an efficient method by which amyloid fibrils can be formed from alpha-synuclein using ionic liquids (ILs). This report indicates that ILs could potentially be used as a stimulator for the amyloid formation of alpha-synuclein.

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Year:  2008        PMID： 19135970     DOI： 10.1016/j.ab.2008.12.019

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  7 in total

1.  Recruitment of class I hydrophobins to the air:water interface initiates a multi-step process of functional amyloid formation.

Authors:  Vanessa K Morris; Qin Ren; Ingrid Macindoe; Ann H Kwan; Nolene Byrne; Margaret Sunde
Journal:  J Biol Chem       Date:  2011-03-18       Impact factor: 5.157

Review 2.  Suppression and dissolution of amyloid aggregates using ionic liquids.

Authors:  Takahiro Takekiyo; Yukihiro Yoshimura
Journal:  Biophys Rev       Date:  2018-04-25

3.  Ionic liquids in protein amyloidogenesis: a brief screenshot of the state-of-the-art.

Authors:  Visakh V S Pillai; Antonio Benedetto
Journal:  Biophys Rev       Date:  2018-05-03

Review 4.  Role of ionic liquids on stabilization of therapeutic proteins and model proteins.

Authors:  Maya Guncheva
Journal:  Protein J       Date:  2022-06-04       Impact factor: 4.000

Review 5.  Recent advances in our understanding of neurodegeneration.

Authors:  Kurt A Jellinger
Journal:  J Neural Transm (Vienna)       Date:  2009-06-05       Impact factor: 3.575

6.  Conformational dynamics of amyloid-β (16-22) peptide in aqueous ionic liquids.

Authors:  Sathish Dasari; Bhabani S Mallik
Journal:  RSC Adv       Date:  2020-09-08       Impact factor: 4.036

7.  Effect of 1-Ethyl-3-methylimidazolium Tetrafluoroborate and Acetate Ionic Liquids on Stability and Amyloid Aggregation of Lysozyme.

Authors:  Diana Fedunova; Andrea Antosova; Jozef Marek; Vladimir Vanik; Erna Demjen; Zuzana Bednarikova; Zuzana Gazova
Journal:  Int J Mol Sci       Date:  2022-01-11       Impact factor: 5.923
  7 in total

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