Literature DB >> 19135883

When sirtuins and NF-kappaB collide.

Gioacchino Natoli1.   

Abstract

Both the sirtuins and certain transcription factors of the NF-kappaB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-kappaB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.

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Year:  2009        PMID： 19135883     DOI： 10.1016/j.cell.2008.12.034

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  13 in total

1.  NF-κB in Aging and Disease.

Authors:  Jeremy S Tilstra; Cheryl L Clauson; Laura J Niedernhofer; Paul D Robbins
Journal:  Aging Dis       Date:  2011-12-02       Impact factor: 6.745

2.  NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Authors:  Jeremy S Tilstra; Andria R Robinson; Jin Wang; Siobhán Q Gregg; Cheryl L Clauson; Daniel P Reay; Luigi A Nasto; Claudette M St Croix; Arvydas Usas; Nam Vo; Johnny Huard; Paula R Clemens; Donna B Stolz; Denis C Guttridge; Simon C Watkins; George A Garinis; Yinsheng Wang; Laura J Niedernhofer; Paul D Robbins
Journal:  J Clin Invest       Date:  2012-06-18       Impact factor: 14.808

Review 3.  NF-κB, the first quarter-century: remarkable progress and outstanding questions.

Authors:  Matthew S Hayden; Sankar Ghosh
Journal:  Genes Dev       Date:  2012-02-01       Impact factor: 11.361

Review 4.  Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation.

Authors:  Charles E McCall; Mohamed El Gazzar; Tiefu Liu; Vidula Vachharajani; Barbara Yoza
Journal:  J Leukoc Biol       Date:  2011-05-24       Impact factor: 4.962

5.  Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients.

Authors:  Jens U Marquardt; Kerstin Fischer; Katharina Baus; Anubha Kashyap; Shengyun Ma; Markus Krupp; Matthias Linke; Andreas Teufel; Ulrich Zechner; Dennis Strand; Snorri S Thorgeirsson; Peter R Galle; Susanne Strand
Journal:  Hepatology       Date:  2013-07-30       Impact factor: 17.425

6.  Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.

Authors:  Wipob Suttana; Samlee Mankhetkorn; Wilart Poompimon; Ajay Palagani; Sergey Zhokhov; Sarah Gerlo; Guy Haegeman; Wim Vanden Berghe
Journal:  Mol Cancer       Date:  2010-05-03       Impact factor: 27.401

7.  Lipopolysaccharide regulates biosynthesis of cystathionine γ-lyase and hydrogen sulfide through Toll-like receptor-4/p38 and Toll-like receptor-4/NF-κB pathways in macrophages.

Authors:  Yijie Zheng; Naixiang Luo; Dongzhen Mu; Pei Jiang; Ronghua Liu; Haozhe Sun; Shudao Xiong; Xiaoming Liu; Luman Wang; Yiwei Chu
Journal:  In Vitro Cell Dev Biol Anim       Date:  2013-07-23       Impact factor: 2.416

8.  Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.

Authors:  Yang Chen; Tao Sun; Junzhen Wu; Bill Kalionis; Changcheng Zhang; Ding Yuan; Jianhua Huang; Waijiao Cai; Hong Fang; Shijin Xia
Journal:  Biomed Res Int       Date:  2015-01-20       Impact factor: 3.411

9.  Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.

Authors:  Sadhana A Samant; Vinodkumar B Pillai; Mahesh P Gupta
Journal:  JCSM Rapid Commun       Date:  2020-12-23

10.  Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.

Authors:  Rong Liu; Hua Liu; Yonju Ha; Ronald G Tilton; Wenbo Zhang
Journal:  Biomed Res Int       Date:  2014-08-05       Impact factor: 3.411
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