Literature DB >> 19135265

Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use.

Sebastian Jessberger1, Fred H Gage.   

Abstract

Adult hippocampal stem/progenitor cells (AHPs) continuously give rise to new neurons throughout life, which might be an important determinant of hippocampus-dependent function. Strikingly, the fate potential of AHPs is not restricted to the neuronal lineage because AHPs can be genetically induced to generate oligodendrocytes within their in vivo niche by AHP-specific ectopic expression of the basic-helix-loop-helix (bHLH) transcription factor achaete-scute complex-like 1 (ASCL1). Fate plasticity of AHPs is controlled by cell-autonomous and also niche-dependent mechanisms. Here, we discuss the biological importance and potential therapeutic applications of retained fate plasticity of AHPs in the adult mammalian brain in addition to the future scientific inquiries indicated by this finding.

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Year:  2009        PMID： 19135265      PMCID： PMC2752320          DOI： 10.1016/j.tips.2008.11.003

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  34 in total

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2.  Cell culture. Progenitor cells from human brain after death.

Authors:  T D Palmer; P H Schwartz; P Taupin; B Kaspar; S A Stein; F H Gage
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3.  Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro.

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4.  Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment.

Authors:  Gerd Kempermann; Daniela Gast; Fred H Gage
Journal:  Ann Neurol       Date:  2002-08       Impact factor: 10.422

5.  The adult substantia nigra contains progenitor cells with neurogenic potential.

Authors:  D Chichung Lie; Gustavo Dziewczapolski; Andrew R Willhoite; Brian K Kaspar; Clifford W Shults; Fred H Gage
Journal:  J Neurosci       Date:  2002-08-01       Impact factor: 6.167

6.  In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus.

Authors:  Hoonkyo Suh; Antonella Consiglio; Jasodhara Ray; Toru Sawai; Kevin A D'Amour; Fred H Gage
Journal:  Cell Stem Cell       Date:  2007-11       Impact factor: 24.633

Review 7.  Mammalian neural stem cells.

Authors:  F H Gage
Journal:  Science       Date:  2000-02-25       Impact factor: 47.728

Review 8.  Multiple sclerosis.

Authors:  B Mark Keegan; John H Noseworthy
Journal:  Annu Rev Med       Date:  2002       Impact factor: 13.739

9.  Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.

Authors:  Luca Santarelli; Michael Saxe; Cornelius Gross; Alexandre Surget; Fortunato Battaglia; Stephanie Dulawa; Noelia Weisstaub; James Lee; Ronald Duman; Ottavio Arancio; Catherine Belzung; René Hen
Journal:  Science       Date:  2003-08-08       Impact factor: 47.728

10.  Functional neurogenesis in the adult hippocampus.

Authors:  Henriette van Praag; Alejandro F Schinder; Brian R Christie; Nicolas Toni; Theo D Palmer; Fred H Gage
Journal:  Nature       Date:  2002-02-28       Impact factor: 69.504
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  8 in total

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Review 3.  Engineering of Adult Neurogenesis and Gliogenesis.

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Journal:  Cold Spring Harb Perspect Biol       Date:  2016-05-02       Impact factor: 10.005

4.  Contribution of constitutively proliferating precursor cell subtypes to dentate neurogenesis after cortical infarcts.

Authors:  Silke Keiner; Josephine Walter; Julia Oberland; Christoph Redecker
Journal:  BMC Neurosci       Date:  2010-11-17       Impact factor: 3.288

5.  The roles of BDNF, pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine.

Authors:  Scarlett B Pinnock; Alastair M Blake; Nicola J Platt; Joe Herbert
Journal:  PLoS One       Date:  2010-10-27       Impact factor: 3.240

6.  High throughput analysis of neural progenitor cell proliferation in adult rodent hippocampus.

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Journal:  Biosci Trends       Date:  2009-12       Impact factor: 2.400

7.  Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain.

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Journal:  PLoS One       Date:  2017-02-03       Impact factor: 3.240

8.  Intranasal delivery of plasma and platelet growth factors using PRGF-Endoret system enhances neurogenesis in a mouse model of Alzheimer's disease.

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  8 in total

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