| Literature DB >> 19135248 |
Shaojun Guo1, Dan Li, Lixue Zhang, Jing Li, Erkang Wang.
Abstract
In this contribution, we report a facile, gram-scale, low-cost route to prepare monodisperse superparamagnetic single-crystal magnetite NPs with mesoporous structure (MSSMN) via a very simple solvothermal method. The formation mechanism of MSSMN is also discussed and we think that Ostwald ripening probably plays an important role in this synthesis process. It is also interestingly found that the size and morphology of mesoporous Fe(3)O(4) NPs can be easily controlled by changing the amount of NaOH and 1,2-ethylenediamine (ETH). Most importantly, the MSSMN can be used as an effective drug delivery carrier. A typical anticancer drug, doxorubicin (Dox), is used for drug loading, and the release behaviors of Dox in two different pH solutions are studied. The results indicate that the MSSMN has a high drug loading capacity and favorable release property for Dox; thus, it is very promising for the application in drug delivery.Entities:
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Year: 2009 PMID： 19135248 DOI： 10.1016/j.biomaterials.2008.12.042
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479