| Literature DB >> 19135181 |
Mariana A Antunes1, Soraia C Abreu, Nilsa R Damaceno-Rodrigues, Edwin R Parra, Vera L Capelozzi, Mariona Pinart, Pablo V Romero, Patrícia M R Silva, Marco Aurélio Martins, Patricia R M Rocco.
Abstract
The impact of genetic factors on asthma is well recognized but poorly understood. We tested the hypothesis that different mouse strains present different lung tissue strip mechanics in a model of chronic allergic asthma and that these mechanical differences may be potentially related to changes of extracellular matrix composition and/or contractile elements in lung parenchyma. Oscillatory mechanics were analysed before and after acetylcholine (ACh) in C57BL/10, BALB/c, and A/J mice, subjected or not to ovalbumin sensitization and challenge. In controls, tissue elastance (E) and resistance (R), collagen and elastic fibres' content, and alpha-actin were higher in A/J compared to BALB/c mice, which, in turn, were more elevated than in C57BL/10. A similar response pattern was observed in ovalbumin-challenged animals irrespective of mouse strain. E and R augmented more in ovalbumin-challenged A/J [E: 22%, R: 18%] than C57BL/10 mice [E: 9.4%, R: 11%] after ACh In conclusion, lung parenchyma remodelled differently yielding distinct in vitro mechanics according to mouse strain.Entities:
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Year: 2008 PMID： 19135181 DOI： 10.1016/j.resp.2008.12.003
Source DB: PubMed Journal: Respir Physiol Neurobiol ISSN： 1569-9048 Impact factor: 1.931