| Literature DB >> 19135105 |
Csilla Hegedus1, Gergely Szakács, László Homolya, Tamás I Orbán, Agnes Telbisz, Márton Jani, Balázs Sarkadi.
Abstract
The major aim of this chapter is to provide a critical overview of the in vitro methods available for studying the function of the ABCG2 multidrug transporter protein. When describing the most applicable assay systems, in each case we present a short overview relevant to ABC multidrug transporters in general, and then we concentrate on the tools applicable to analysis of substrate-drug interactions, the effects of potential activators and inhibitors, and the role of polymorphisms of the ABCG2 transporter. Throughout this chapter we focus on recently developed assay systems, which may provide new possibilities for analyzing the pharmacological aspects of this medically important protein.Entities:
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Year: 2008 PMID： 19135105 DOI： 10.1016/j.addr.2008.09.007
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470