OBJECTIVES: We conducted a proof of concept study to determine the feasibility of using an individual psychotherapy, Interpersonal and Social Rhythm Therapy (IPSRT), as monotherapy for the acute treatment of bipolar II depression. METHODS:Unmedicated individuals (n = 17) meeting DSM-IV criteria for bipolar II disorder and currently depressed received weeklypsychotherapy (IPSRT) for 12 weeks. After 12 weeks of acute treatment, individuals received an additional 8 weeks of follow-up treatment consisting of continued weekly IPSRT with supplementary lamotrogine for IPSRT non-responders. RESULTS: By week 12, 41% (n = 7) of the sample responded to IPSRT monotherapy (defined as > or =50% reduction in depression scores without an increase in mania scores), 41% (n = 7) dropped out of or were removed from the study, and 18% (n = 3) did not respond to treatment. By week 20, 53% (n = 9) had achieved a response and 29% (n = 5) achieved a full remission of symptoms. CONCLUSIONS:Interpersonal and Social Rhythm Therapy appears to be a promising intervention for a subset of individuals with bipolar II depression. A randomized controlled trial is needed to systematically evaluate the efficacy of IPSRT as an acute monotherapy for bipolar II depression.
RCT Entities:
OBJECTIVES: We conducted a proof of concept study to determine the feasibility of using an individual psychotherapy, Interpersonal and Social Rhythm Therapy (IPSRT), as monotherapy for the acute treatment of bipolar II depression. METHODS: Unmedicated individuals (n = 17) meeting DSM-IV criteria for bipolar II disorder and currently depressed received weekly psychotherapy (IPSRT) for 12 weeks. After 12 weeks of acute treatment, individuals received an additional 8 weeks of follow-up treatment consisting of continued weekly IPSRT with supplementary lamotrogine for IPSRT non-responders. RESULTS: By week 12, 41% (n = 7) of the sample responded to IPSRT monotherapy (defined as > or =50% reduction in depression scores without an increase in mania scores), 41% (n = 7) dropped out of or were removed from the study, and 18% (n = 3) did not respond to treatment. By week 20, 53% (n = 9) had achieved a response and 29% (n = 5) achieved a full remission of symptoms. CONCLUSIONS: Interpersonal and Social Rhythm Therapy appears to be a promising intervention for a subset of individuals with bipolar II depression. A randomized controlled trial is needed to systematically evaluate the efficacy of IPSRT as an acute monotherapy for bipolar II depression.
Authors: Lewis L Judd; Hagop S Akiskal; Pamela J Schettler; William Coryell; Jack Maser; John A Rice; David A Solomon; Martin B Keller Journal: J Affect Disord Date: 2003-01 Impact factor: 4.839
Authors: Holly A Swartz; Paola Rucci; Michael E Thase; Meredith Wallace; Elisa Carretta; Karen L Celedonia; Ellen Frank Journal: J Clin Psychiatry Date: 2018 Mar/Apr Impact factor: 4.384
Authors: Elaine M Boland; Rachel E Bender; Lauren B Alloy; Bradley T Conner; Denise R Labelle; Lyn Y Abramson Journal: J Affect Disord Date: 2012-02-29 Impact factor: 4.839