OBJECTIVES: Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. METHODS: We assessed polarity at onset in patients with bipolar I disorder (N = 553) recruited as part of our ongoing studies of affective disorders. Lifetime clinical characteristics of illness were compared in patients who had a depressive episode at first illness onset (n = 343) and patients who had a manic episode at first illness onset (n = 210). RESULTS: Several lifetime clinical features differed between patients according to the polarity of their onset episode of illness. A logistic regression analysis showed that the lifetime clinical features significantly associated with a depressive episode at illness onset in our sample were: an earlier age at illness onset; a predominantly depressive polarity during the lifetime; more frequent and more severe depressive episodes; and less prominent lifetime psychotic features. CONCLUSIONS: Knowledge of pole of onset may help the clinician in providing prognostic information and management advice to an individual with bipolar disorder.
OBJECTIVES: Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. METHODS: We assessed polarity at onset in patients with bipolar I disorder (N = 553) recruited as part of our ongoing studies of affective disorders. Lifetime clinical characteristics of illness were compared in patients who had a depressive episode at first illness onset (n = 343) and patients who had a manic episode at first illness onset (n = 210). RESULTS: Several lifetime clinical features differed between patients according to the polarity of their onset episode of illness. A logistic regression analysis showed that the lifetime clinical features significantly associated with a depressive episode at illness onset in our sample were: an earlier age at illness onset; a predominantly depressive polarity during the lifetime; more frequent and more severe depressive episodes; and less prominent lifetime psychotic features. CONCLUSIONS: Knowledge of pole of onset may help the clinician in providing prognostic information and management advice to an individual with bipolar disorder.
Authors: Julia W Y Kam; Amanda R Bolbecker; Brian F O'Donnell; William P Hetrick; Colleen A Brenner Journal: J Affect Disord Date: 2011-07-23 Impact factor: 4.839
Authors: Andre F Carvalho; João Quevedo; Roger S McIntyre; Márcio G Soeiro-de-Souza; Konstantinos N Fountoulakis; Michael Berk; Thomas N Hyphantis; Eduard Vieta Journal: Int J Neuropsychopharmacol Date: 2014-10-31 Impact factor: 5.176
Authors: Rafael O'Halloran; Brian H Kopell; Emma Sprooten; Wayne K Goodman; Sophia Frangou Journal: Front Psychiatry Date: 2016-04-19 Impact factor: 4.157