AIM: To investigate trends in mortality and morbidity in very preterm infants. METHODS: Population-based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995-2004). Time trends for mortality and common morbidities were explored using logistic regression analyses. RESULTS: Data from 1614 liveborn infants were included. There was an increase in live born infants below 25 gestational weeks, annual odds ratio (OR) 1.15 (95% CI: 1.08-1.23) and a decrease in mortality annual OR 0.82 (95% CI: 0.69-0.98). The rates of bronchopulmonary dysplasia (BPD) and sepsis increased during the study period, annual ORs of 1.10 (95% CI: 1.04-1.17) and 1.09 (95% CI: 1.03-1.16). The duration of mechanical ventilation increased for surviving infants <25 gestational weeks (p = 0.003), while the duration of continuous positive airway pressure (CPAP) increased for infants <28 gestational weeks (p = <0.001). There were no changes in the rates of intraventricular haemorrhages (IVH, 3-4), retinopathy of prematurity (ROP, 3-5), seizures or necrotizing enterocolitis (NEC). CONCLUSION: During the 10-year period changes in mortality and morbidity were most pronounced for infants with GA <28 gestational weeks. The increasing rate of sepsis was present in infants <28 gestational weeks, whereas the increase in BPD was demonstrated in the whole study population <32 gestational weeks.
AIM: To investigate trends in mortality and morbidity in very preterm infants. METHODS: Population-based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995-2004). Time trends for mortality and common morbidities were explored using logistic regression analyses. RESULTS: Data from 1614 liveborn infants were included. There was an increase in live born infants below 25 gestational weeks, annual odds ratio (OR) 1.15 (95% CI: 1.08-1.23) and a decrease in mortality annual OR 0.82 (95% CI: 0.69-0.98). The rates of bronchopulmonary dysplasia (BPD) and sepsis increased during the study period, annual ORs of 1.10 (95% CI: 1.04-1.17) and 1.09 (95% CI: 1.03-1.16). The duration of mechanical ventilation increased for surviving infants <25 gestational weeks (p = 0.003), while the duration of continuous positive airway pressure (CPAP) increased for infants <28 gestational weeks (p = <0.001). There were no changes in the rates of intraventricular haemorrhages (IVH, 3-4), retinopathy of prematurity (ROP, 3-5), seizures or necrotizing enterocolitis (NEC). CONCLUSION: During the 10-year period changes in mortality and morbidity were most pronounced for infants with GA <28 gestational weeks. The increasing rate of sepsis was present in infants <28 gestational weeks, whereas the increase in BPD was demonstrated in the whole study population <32 gestational weeks.
Authors: Debora Duro; Leslie A Kalish; Patrick Johnston; Tom Jaksic; Maggie McCarthy; Cami Martin; James C Y Dunn; Mary Brandt; Kerilyn K Nobuhara; Karl G Sylvester; R Lawrence Moss; Christopher Duggan Journal: J Pediatr Date: 2010-05-06 Impact factor: 4.406
Authors: Christopher A Lear; Miriam E Koome; Joanne O Davidson; Paul P Drury; Josine S Quaedackers; Robert Galinsky; Alistair J Gunn; Laura Bennet Journal: J Physiol Date: 2014-11-10 Impact factor: 5.182
Authors: S Desai; G Athalye-Jape; S Madhala; W Tee; M Sharp; E Nathan; D Shrestha; S Patole Journal: AJNR Am J Neuroradiol Date: 2022-02-24 Impact factor: 3.825
Authors: Wes Onland; Thomas P Debray; Matthew M Laughon; Martijn Miedema; Filip Cools; Lisa M Askie; Jeanette M Asselin; Sandra A Calvert; Sherry E Courtney; Carlo Dani; David J Durand; Neil Marlow; Janet L Peacock; J Jane Pillow; Roger F Soll; Ulrich H Thome; Patrick Truffert; Michael D Schreiber; Patrick Van Reempts; Valentina Vendettuoli; Giovanni Vento; Anton H van Kaam; Karel G Moons; Martin Offringa Journal: BMC Pediatr Date: 2013-12-17 Impact factor: 2.125