BACKGROUND: we have recently published the hypothesis that hypocholesterolemia might be a risk factor for the development of pulmonary tuberculosis. In this sense, albeit patients with pulmonary tuberculosis often have total cholesterol levels lower than the general population, it is not known if the latter have had a recent exposure to Mycobacterium tuberculosis. OBJECTIVE: to evaluate serum lipids in subjects exposed to mycobacteria. METHODS: we studied 25 pulmonary tuberculosis patients and 44 household contacts, and compared their serum lipid profile. RESULTS: We found that total cholesterol, LDL and triglycerides concentrations increased with age in contacts but not in pulmonary tuberculosis patients, with statistically significant differences in regression lines (age versus lipid level). Multiple linear regression analysis confirmed that being a household contact was associated with higher levels of total cholesterol, LDL, HDL and triglycerides. CONCLUSIONS: We conclude that lipid profile differed between pulmonary tuberculosis patients and their household contacts, thus supporting that low cholesterol levels might be a risk factor for developing pulmonary tuberculosis.
BACKGROUND: we have recently published the hypothesis that hypocholesterolemia might be a risk factor for the development of pulmonary tuberculosis. In this sense, albeit patients with pulmonary tuberculosis often have total cholesterol levels lower than the general population, it is not known if the latter have had a recent exposure to Mycobacterium tuberculosis. OBJECTIVE: to evaluate serum lipids in subjects exposed to mycobacteria. METHODS: we studied 25 pulmonary tuberculosispatients and 44 household contacts, and compared their serum lipid profile. RESULTS: We found that total cholesterol, LDL and triglycerides concentrations increased with age in contacts but not in pulmonary tuberculosispatients, with statistically significant differences in regression lines (age versus lipid level). Multiple linear regression analysis confirmed that being a household contact was associated with higher levels of total cholesterol, LDL, HDL and triglycerides. CONCLUSIONS: We conclude that lipid profile differed between pulmonary tuberculosispatients and their household contacts, thus supporting that low cholesterol levels might be a risk factor for developing pulmonary tuberculosis.
Authors: John Mukisa; Ismael Kawooya; Joan Nangendo; Annet Nalutaaya; Jean Nyamwiza; Ali Sam; Ronald Ssenyonga; William Worodria; Ezekiel Mupere Journal: Afr Health Sci Date: 2018-09 Impact factor: 0.927