BACKGROUND: We retrospectively reviewed outcomes in patients treated with radiotherapy (RT) for cutaneous head and neck carcinoma with perineural invasion (PNI), with the aim of developing risk-adapted treatment guidelines. METHODS: A total of 118 patients were treated with RT between April 1992 and July 2000. Ninety-seven patients had PNI discovered through histology (pPNI) and 21 patients had symptoms/signs of PNI (cPNI). All received RT (median dose, 55 Gy; range, 17-74): 114 postoperatively and 4 definitively. Median follow-up was 84 months (range, 4-201). RESULTS: The 5-year local control (LC) rates were 90% with pPNI and 57% with cPNI (p < .0001). The pPNI and cPNI groups also differed in relapse-free survival (76% vs 46%, p = .003), disease-specific survival (90% vs 76%, p = .002), and overall survival (69% vs 57%, p = .03). pPNI patients with BCC histology (n = 42) had better LC (97% vs 84%, p = .02) than pPNI SCC (n = 55). CONCLUSION: Surgery plus RT provides a high rate of LC in patients with pPNI, particularly those with BCC. Therapeutic improvements are needed for patients with cPNI.
BACKGROUND: We retrospectively reviewed outcomes in patients treated with radiotherapy (RT) for cutaneous head and neck carcinoma with perineural invasion (PNI), with the aim of developing risk-adapted treatment guidelines. METHODS: A total of 118 patients were treated with RT between April 1992 and July 2000. Ninety-seven patients had PNI discovered through histology (pPNI) and 21 patients had symptoms/signs of PNI (cPNI). All received RT (median dose, 55 Gy; range, 17-74): 114 postoperatively and 4 definitively. Median follow-up was 84 months (range, 4-201). RESULTS: The 5-year local control (LC) rates were 90% with pPNI and 57% with cPNI (p < .0001). The pPNI and cPNI groups also differed in relapse-free survival (76% vs 46%, p = .003), disease-specific survival (90% vs 76%, p = .002), and overall survival (69% vs 57%, p = .03). pPNIpatients with BCC histology (n = 42) had better LC (97% vs 84%, p = .02) than pPNI SCC (n = 55). CONCLUSION: Surgery plus RT provides a high rate of LC in patients with pPNI, particularly those with BCC. Therapeutic improvements are needed for patients with cPNI.
Authors: Catherine M Barnett; Ryan S Sommerville; Charles Lin; Gishan Ratnayake; Brett Hughes; Touraj Taheri Journal: J Neurol Surg B Skull Base Date: 2018-06-14
Authors: Yusuf Dundar; Richard B Cannon; Marcus M Monroe; Luke Oliver Buchmann; Jason Patrick Hunt Journal: J Neurol Surg B Skull Base Date: 2016-11-23
Authors: Jidapa Bridhikitti; Jason K Viehman; W Scott Harmsen; Adam C Amundson; Satomi Shiraishi; Daniel W Mundy; Jean-Claude M Rwigema; Lisa A McGee; Samir H Patel; David M Routman; Scott C Lester; Michelle A Neben-Wittich; Yolanda I Garces; Daniel J Ma; Robert L Foote Journal: Int J Part Ther Date: 2021-06-25
Authors: Timothy A Warren; Natasa Broit; Jacinta L Simmons; Carly J Pierce; Sharad Chawla; Duncan L J Lambie; Gary Quagliotto; Ian S Brown; Peter G Parsons; Benedict J Panizza; Glen M Boyle Journal: Sci Rep Date: 2016-09-26 Impact factor: 4.379