BACKGROUND: Although community-acquired bacteremia is an important cause of childhood mortality in Africa, recognition of disease burden and potential impact of bacterial vaccines is limited. METHODS: Blood cultures for bacterial pathogens were conducted systematically among children <15 years of age admitted to Manhiça District Hospital, from 2001 to 2006. RESULTS: Blood-stream infections were identified in 8% (1550/19,896) of pediatric hospital admissions. Nontyphoidal Salmonella (NTS) and Pneumococcus were the most prevalent pathogens isolated (26% and 25% of 1550 cases, respectively). Until 28 days of life, Staphylococcus aureus (39%) and group B Streptococcus (20%) predominated. Incidence of community-acquired bacteremia per 100,000 child-years was 1730/10 in children <1 year old, 782/10 in 1-4 year oldd, and 49/10 in children 5 years and older. Case-fatality of bacteremia was 12%. Community-acquired bacteremia associated mortality accounted for 21% (162/788) of hospital deaths. Resistance to antibiotics commonly used in Mozambique was high among invasive isolates of Haemophilus influenzae, Escherichia coli, and NTS. CONCLUSIONS: Community-acquired bacteremia is an important cause of pediatric hospital admission and death in rural African hospitals. The high burden of disease, mortality, and pattern of antibiotic resistance associated with bacteremia underscore the need for prevention in Sub-Saharan Africa.
BACKGROUND: Although community-acquired bacteremia is an important cause of childhood mortality in Africa, recognition of disease burden and potential impact of bacterial vaccines is limited. METHODS: Blood cultures for bacterial pathogens were conducted systematically among children <15 years of age admitted to Manhiça District Hospital, from 2001 to 2006. RESULTS: Blood-stream infections were identified in 8% (1550/19,896) of pediatric hospital admissions. Nontyphoidal Salmonella (NTS) and Pneumococcus were the most prevalent pathogens isolated (26% and 25% of 1550 cases, respectively). Until 28 days of life, Staphylococcus aureus (39%) and group B Streptococcus (20%) predominated. Incidence of community-acquired bacteremia per 100,000 child-years was 1730/10 in children <1 year old, 782/10 in 1-4 year oldd, and 49/10 in children 5 years and older. Case-fatality of bacteremia was 12%. Community-acquired bacteremia associated mortality accounted for 21% (162/788) of hospital deaths. Resistance to antibiotics commonly used in Mozambique was high among invasive isolates of Haemophilus influenzae, Escherichia coli, and NTS. CONCLUSIONS: Community-acquired bacteremia is an important cause of pediatric hospital admission and death in rural African hospitals. The high burden of disease, mortality, and pattern of antibiotic resistance associated with bacteremia underscore the need for prevention in Sub-Saharan Africa.
Authors: Inácio Mandomando; Betuel Sigaúque; Luis Morais; Mateu Espasa; Xavier Vallès; Jahit Sacarlal; Eusébio Macete; Pedro Aide; Llorenç Quintò; Tacilta Nhampossa; Sónia Machevo; Quique Bassat; Clara Menéndez; Joaquim Ruiz; Anna Roca; Pedro L Alonso Journal: Am J Trop Med Hyg Date: 2010-07 Impact factor: 2.345
Authors: Samir K Saha; Zabed B Ahmed; Joyanta K Modak; Hakka Naziat; Shampa Saha; Mohammad A Uddin; Maksuda Islam; Abdullah H Baqui; Gary L Darmstadt; Stephanie J Schrag Journal: J Clin Microbiol Date: 2017-05-17 Impact factor: 5.948
Authors: M Capan; G Mombo-Ngoma; D Akerey-Diop; A Basra; H Würbel; W Lendamba; L Auer-Hackenberg; R Mackanga; J Melser; S Belard; M Ramharter Journal: Wien Klin Wochenschr Date: 2012-10-13 Impact factor: 1.704
Authors: Behzad Nadjm; Ben Amos; George Mtove; Jan Ostermann; Semkini Chonya; Hannah Wangai; Juma Kimera; Walii Msuya; Frank Mtei; Denise Dekker; Rajabu Malahiyo; Raimos Olomi; John A Crump; Christopher J M Whitty; Hugh Reyburn Journal: BMJ Date: 2010-03-30
Authors: Sharon M Tennant; Souleymane Diallo; Haim Levy; Sofie Livio; Samba O Sow; Milagritos Tapia; Patricia I Fields; Matthew Mikoleit; Boubou Tamboura; Karen L Kotloff; James P Nataro; James E Galen; Myron M Levine Journal: PLoS Negl Trop Dis Date: 2010-03-09
Authors: George Mtove; Ben Amos; Lorenz von Seidlein; Ilse Hendriksen; Abraham Mwambuli; Juma Kimera; Rajabu Mallahiyo; Deok Ryun Kim; R Leon Ochiai; John D Clemens; Hugh Reyburn; Stephen Magesa; Jacqueline L Deen Journal: PLoS One Date: 2010-02-16 Impact factor: 3.240