Literature DB >> 19131628

HDAC4 regulates neuronal survival in normal and diseased retinas.

Bo Chen1, Constance L Cepko.   

Abstract

Histone deacetylase 4 (HDAC4) shuttles between the nucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development. We report that HDAC4 regulates the survival of retinal neurons in the mouse in normal and pathological conditions. Reduction in HDAC4 expression during normal retinal development led to apoptosis of rod photoreceptors and bipolar (BP) interneurons, whereas overexpression reduced naturally occurring cell death of the BP cells. HDAC4 overexpression in a mouse model of retinal degeneration prolonged photoreceptor survival. The survival effect was due to the activity of HDAC4 in the cytoplasm and relied at least partly on the activity of hypoxia-inducible factor 1alpha (HIF1alpha). These data provide evidence that HDAC4 plays an important role in promoting the survival of retinal neurons.

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Year:  2009        PMID： 19131628      PMCID： PMC3339762          DOI： 10.1126/science.1166226

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

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Review 3.  HIF-1: mediator of physiological and pathophysiological responses to hypoxia.

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Journal:  Cell       Date:  2004-11-12       Impact factor: 41.582

5.  MEF2C transcription factor controls chondrocyte hypertrophy and bone development.

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6.  HDAC4 deacetylase associates with and represses the MEF2 transcription factor.

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Authors:  Timothy A Bolger; Tso-Pang Yao
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10.  The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.

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  94 in total

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2.  Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival.

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Journal:  Diabetologia       Date:  2010-09-28       Impact factor: 10.122

4.  Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

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Review 5.  Synaptically Localized Transcriptional Regulators in Memory Formation.

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Journal:  Neuroscience       Date:  2017-07-18       Impact factor: 3.590

Review 6.  Next-generation therapeutic solutions for age-related macular degeneration.

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Journal:  Pharm Pat Anal       Date:  2012-05

7.  Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium.

Authors:  Ling X Zhang; Jianfeng Du; Yu Tina Zhao; Jianguo Wang; Shouyan Zhang; Patrycja M Dubielecka; Lei Wei; Shougang Zhuang; Gangjian Qin; Y Eugene Chin; Ting C Zhao
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8.  Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis.

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Review 9.  Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.

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Journal:  J Biomed Biotechnol       Date:  2010-12-05

10.  Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development.

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Journal:  PLoS One       Date:  2009-08-12       Impact factor: 3.240
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