OBJECTIVE: The aim of this study was to determine the effect of common adiponectin gene polymorphisms on dietary intervention-mediated changes in adiponectin levels and homeostasis model assessment of insulin resistance (HOMA-IR) indexes. RESEARCH DESIGN AND METHODS: A total of 363 subjects with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes followed a dietary intervention (replacement of cooked refined rice with whole grains and an increase in vegetable intake) and regular walking for 12 weeks without any medication. Adiponectin gene single nucleotide polymorphisms (SNPs) (45, 276, and -11377) were examined in these subjects. RESULTS: After this dietary intervention, fasting glucose levels decreased in all three SNP 45T>G genotype groups. Subjects with the SNP 45TT genotype showed increased adiponectin levels and decreased HOMA-IR indexes. Haplotype analysis revealed that homozygous carriers of the TG haplotype (45TT and 276GG) and heterozygous carriers of the TG haplotype (TG/X) showed a reduction in the HOMA-IR index after adjustment for baseline levels. Significant differences were observed in changes in HOMA-IR indexes and adiponectin concentrations according to the 45-276 TG haplotype in overweight-obese, but not in normal-weight subjects: the greatest decrease in HOMA-IR indexes and the greatest increase in adiponectin levels were shown in overweight-obese subjects with the TG/TG haplotype. CONCLUSIONS: ADIPOQ genetic variants can affect circulating adiponectin levels and insulin resistance indexes in subjects with IFG or newly diagnosed type 2 diabetes in response to dietary intervention.
OBJECTIVE: The aim of this study was to determine the effect of common adiponectin gene polymorphisms on dietary intervention-mediated changes in adiponectin levels and homeostasis model assessment of insulin resistance (HOMA-IR) indexes. RESEARCH DESIGN AND METHODS: A total of 363 subjects with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes followed a dietary intervention (replacement of cooked refined rice with whole grains and an increase in vegetable intake) and regular walking for 12 weeks without any medication. Adiponectin gene single nucleotide polymorphisms (SNPs) (45, 276, and -11377) were examined in these subjects. RESULTS: After this dietary intervention, fasting glucose levels decreased in all three SNP 45T>G genotype groups. Subjects with the SNP 45TT genotype showed increased adiponectin levels and decreased HOMA-IR indexes. Haplotype analysis revealed that homozygous carriers of the TG haplotype (45TT and 276GG) and heterozygous carriers of the TG haplotype (TG/X) showed a reduction in the HOMA-IR index after adjustment for baseline levels. Significant differences were observed in changes in HOMA-IR indexes and adiponectin concentrations according to the 45-276 TG haplotype in overweight-obese, but not in normal-weight subjects: the greatest decrease in HOMA-IR indexes and the greatest increase in adiponectin levels were shown in overweight-obese subjects with the TG/TG haplotype. CONCLUSIONS:ADIPOQ genetic variants can affect circulating adiponectin levels and insulin resistance indexes in subjects with IFG or newly diagnosed type 2 diabetes in response to dietary intervention.
Authors: K Hotta; T Funahashi; Y Arita; M Takahashi; M Matsuda; Y Okamoto; H Iwahashi; H Kuriyama; N Ouchi; K Maeda; M Nishida; S Kihara; N Sakai; T Nakajima; K Hasegawa; M Muraguchi; Y Ohmoto; T Nakamura; S Yamashita; T Hanafusa; Y Matsuzawa Journal: Arterioscler Thromb Vasc Biol Date: 2000-06 Impact factor: 8.311
Authors: M Takahashi; Y Arita; K Yamagata; Y Matsukawa; K Okutomi; M Horie; I Shimomura; K Hotta; H Kuriyama; S Kihara; T Nakamura; S Yamashita; T Funahashi; Y Matsuzawa Journal: Int J Obes Relat Metab Disord Date: 2000-07
Authors: N Vionnet; El H Hani; S Dupont; S Gallina; S Francke; S Dotte; F De Matos; E Durand; F Leprêtre; C Lecoeur; P Gallina; L Zekiri; C Dina; P Froguel Journal: Am J Hum Genet Date: 2000-11-06 Impact factor: 11.025
Authors: Claudia Menzaghi; Tonino Ercolino; Rosa Di Paola; Anders H Berg; James H Warram; Philipp E Scherer; Vincenzo Trischitta; Alessandro Doria Journal: Diabetes Date: 2002-07 Impact factor: 9.461
Authors: Yangsoo Jang; Jey Sook Chae; Soo Jeong Koh; Yae Jung Hyun; Ji Young Kim; Yeo Jin Jeong; Sungha Park; Chul-Min Ahn; Jong Ho Lee Journal: Clin Chim Acta Date: 2008-02-16 Impact factor: 3.786
Authors: Panga Jaipal Reddy; Rekha Jain; Young-Ki Paik; Robin Downey; Adam S Ptolemy; Vural Ozdemir; Sanjeeva Srivastava Journal: Curr Pharmacogenomics Person Med Date: 2011-03-01
Authors: J S R Machado; A C T Palei; L M Amaral; A C Bueno; S R Antonini; G Duarte; J E Tanus-Santos; V C Sandrim; R C Cavalli Journal: J Hum Hypertens Date: 2013-06-27 Impact factor: 3.012