| Literature DB >> 19131247 |
Robert J Cherney1, John B Brogan, Ruowei Mo, Yvonne C Lo, Gengjie Yang, Persymphonie B Miller, Peggy A Scherle, Bruce F Molino, Percy H Carter, Carl P Decicco.
Abstract
A series of trisubstituted cyclohexanes was designed, synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the identification of two distinct substitution patterns about the cyclohexane ring as potent and selective CCR2 antagonists. Compound 36 exhibited excellent binding (CCR2 IC(50)=2.4 nM) and functional antagonism (calcium flux IC(50)=2.0 nM and chemotaxis IC(50)=5.1 nM).Entities:
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Year: 2008 PMID： 19131247 DOI： 10.1016/j.bmcl.2008.12.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823